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X. Zhao
Publications - 1
Citations - 48
X. Zhao is an academic researcher. The author has contributed to research in topics: Allosteric regulation. The author has an hindex of 1, co-authored 1 publications receiving 18 citations.
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Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C.
Jason Grant Kettle,Sharanjeet Kaur Bagal,Sue Bickerton,Bodnarchuk,Jason Breed,Rodrigo J. Carbajo,Doyle Joseph Cassar,A. Chakraborty,Sabina Cosulich,Iain A. Cumming,Michael Davies,Andrew John Eatherton,L. Evans,Lyman Feron,Shaun M. Fillery,E.S. Gleave,Frederick W. Goldberg,S. Harlfinger,Lyndsey Hanson,M.R. Howard,Rachel L. Howells,A. Jackson,Paul D. Kemmitt,J.K. Kingston,Scott G. Lamont,Hilary J. Lewis,S. Li,L. Liu,Derek Ogg,Christopher R. Phillips,Radoslaw Polanski,Graeme R. Robb,David Robinson,Sarah Ross,James M. Smith,Michael Tonge,Rebecca Whiteley,Jun Yang,L. Zhang,X. Zhao +39 more
TL;DR: Attempts to directly drug the important oncogene KRAS have met with limited success despite numerous efforts across industry and academia, and the KRASG12C mutant represents an “Achilles heel” and has ...