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Xavier Michalet
Researcher at University of California, Los Angeles
Publications - 142
Citations - 15525
Xavier Michalet is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Photon counting & Detector. The author has an hindex of 39, co-authored 130 publications receiving 14452 citations. Previous affiliations of Xavier Michalet include Pasteur Institute & Lawrence Berkeley National Laboratory.
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Journal ArticleDOI
Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
Xavier Michalet,Fabien Pinaud,Laurent A. Bentolila,James M. Tsay,Sören Doose,J. Jack Li,Gobalakrishnan Sundaresan,Anna M. Wu,Sanjiv S. Gambhir,Sanjiv S. Gambhir,Shimon Weiss +10 more
TL;DR: The new generations of qdots have far-reaching potential for the study of intracellular processes at the single-molecule level, high-resolution cellular imaging, long-term in vivo observation of cell trafficking, tumor targeting, and diagnostics.
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Dynamic Molecular Combing: Stretching the Whole Human Genome for High-Resolution Studies
Xavier Michalet,Rosemary Ekong,Françoise Fougerousse,Sophie Rousseaux,Catherine Schurra,Nick Hornigold,Marjon van Slegtenhorst,Jonathan Wolfe,Sue Povey,Jacques S. Beckmann,Aaron Bensimon +10 more
TL;DR: DNA in amounts representative of hundreds of eukaryotic genomes was extended on silanized surfaces by dynamic molecular combing and the precise measurement of hybridized DNA probes was achieved directly without requiring normalization, making it a powerful tool for a variety of genomic studies.
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Mean square displacement analysis of single-particle trajectories with localization error: Brownian motion in an isotropic medium.
TL;DR: In this paper, the capability of mean square displacement (MSD) analysis to extract reliable values of the diffusion coefficient D of a single particle undergoing Brownian motion in an isotropic medium in the presence of localization uncertainty was examined.
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Single-Molecule Fluorescence Studies of Protein Folding and Conformational Dynamics
TL;DR: A review of single-molecule methods in chemistry to provide a rapid description of the main technical approaches and focus on a few illustrative examples of their elucidative power, and describes applications of a unique set of methods to biochemical questions and, more specifically, the elucidation of protein structure, dynamics, and function.
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Advances in fluorescence imaging with quantum dot bio-probes
Fabien Pinaud,Xavier Michalet,Laurent A. Bentolila,James M. Tsay,Sören Doose,Jack Li,Gopal Iyer,Shimon Weiss +7 more
TL;DR: The unique properties of qdots not only give biologists the opportunity to explore advanced imaging techniques such as single molecule or lifetime imaging but also to revisit traditional fluorescence imaging methodologies and extract yet unobserved or inaccessible information in vitro or in vivo.