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Xia Li
Researcher at Nantong University
Publications - 45
Citations - 698
Xia Li is an academic researcher from Nantong University. The author has contributed to research in topics: Arthritis & Computer science. The author has an hindex of 14, co-authored 31 publications receiving 542 citations.
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Journal ArticleDOI
Osteoclast-Derived Extracellular Vesicles: Novel Regulators of Osteoclastogenesis and Osteoclast-Osteoblasts Communication in Bone Remodeling.
Feng-Lai Yuan,Qian-Yuan Wu,Zong-Ning Miao,Ming-Hui Xu,Rui-Sheng Xu,Dong-Lin Jiang,Jun-Xing Ye,Fei-Hu Chen,Mingdong Zhao,Hao-Jue Wang,Xia Li +10 more
TL;DR: Recent advances in the field of osteoclast-derived EVs in bone remodeling regulation are reviewed, summarizing a new regulator of osteoporosis and osteOClast–osteoblast communication mediated by osteoc Last- derived EVs.
Journal ArticleDOI
Acid-sensing ion channel 1a-mediated calcium influx regulates apoptosis of endplate chondrocytes in intervertebral discs.
TL;DR: It is demonstrated that the acid-induced [Ca2+]i increase via ASIC1a is involved in endplate chondrocyte apoptosis, which may trigger Ca2+-dependent proteases activity and signaling, which leads to apoptosis of end plate chonrocytes in IVDs.
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Leonurine hydrochloride inhibits osteoclastogenesis and prevents osteoporosis associated with estrogen deficiency by inhibiting the NF-κB and PI3K/Akt signaling pathways
TL;DR: In this study, LH suppressed RANKL-induced osteoclastogenesis via RANK-TRAF6, NF-κB, and PI3K/Akt signaling, thus preventing bone loss caused by estrogen deficiency in mice and providing the first evidence that LH might be a promising therapeutic compound to treat osteoporosis.
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The Roles of Acidosis in Osteoclast Biology.
TL;DR: The recent investigations into the effects of acidosis in osteoclast biology and the acid-sensing molecular mechanism are discussed.
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Targeting interleukin-21 in rheumatoid arthritis.
Feng-Lai Yuan,Wei Hu,Wei-Guo Lu,Xia Li,Jian-Ping Li,Rui-Sheng Xu,Cheng-Wan Li,Fei-Hu Chen,Cheng Jin +8 more
TL;DR: Findings suggest that IL-21 has important biological effects in autoimmunity that might be a promising therapeutic target for RA and recent advances in the role of IL- 21 in the pathogenesis and treatment of RA are summarized.