Xia Shen

TL;DR: The findings suggest the cellular basis and the potential prevention and treatment strategies for anesthesia-induced cognitive impairment, which may ultimately lead to safer anesthesia care and better postoperative outcomes for children.

TL;DR: Analysis of the contribution of OPN to the intrinsic functions of this CD11c+ microglial subset indicates that OPN is required for subset stability and the execution of phagocytic and proinflammatory responses, in part through OPN-dependent engagement of the αVβ3-integrin receptor.

TL;DR: It is shown for the first time that treatment with BACE and APP siRNAs can decrease levels of BACE, full-length APP, and APP c-terminal fragments, and the treatment attenuates the Aβ levels and the isoflurane-induced caspase-3 activation.

TL;DR: The authors identified a pathogenic microglial subset which expressed the CD11c surface marker as the sole producer of Osteopontin (OPN) in the 5XFAD mouse model of Alzheimer's disease.

TL;DR: A pathway to interfere with regulatory T cell stability by disrupting the expression of the interleukin 23 receptor is reported, leading to increased production of gamma-interferon and more efficient antitumor immune responses.