Xiao-Li Xu

TL;DR: This work successfully designed and characterized the most potent protein-protein interaction (PPI) inhibitor of Keap1-Nrf2, compound 2, with K(D) value of 3.59 nM binding to Keap 1 for the first time to single-digit nanomolar.

TL;DR: Findings indicate that NRF2 silencing-mediated reduction of RhoA expression contributes, at least in part, to the poor outcome of breast cancer patients with highNRF2 expression.

TL;DR: This review summarizes the recent progress in Hsp90 inhibitors and suggests novel HSp90 inhibitory strategies that are expected to breakthrough with satisfactory efficacy and safety profiles.

TL;DR: Compound 18e could reduce the level of circulating pro-inflammatory cytokines induced by LPS and relieve the inflammatory response, and a preliminary investigation of the structure-activity and structure-property relationships of the ring systems to improve the drug-like properties was conducted.

TL;DR: The current understanding of STING structure is summarized, the status quo of STings modulators is surveyed, established bioassay methods are compared, the chemical structures and bioactivities of agonists and inhibitors are reviewed, and suggestions and insights for the future exploitation of STing modulators are proposed.