L
Li-Li Xu
Researcher at China Pharmaceutical University
Publications - 23
Citations - 648
Li-Li Xu is an academic researcher from China Pharmaceutical University. The author has contributed to research in topics: Inflammasome & Pyrin domain. The author has an hindex of 13, co-authored 23 publications receiving 428 citations. Previous affiliations of Li-Li Xu include Chinese Ministry of Education.
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Journal ArticleDOI
NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction.
Chao Zhang,Hui-Jie Wang,Qi-Chao Bao,Lei Wang,Tian-kun Guo,Wei-Lin Chen,Li-Li Xu,Hai-Shan Zhou,Jinlei Bian,Ying-Rui Yang,Haopeng Sun,Xiao-Li Xu,Qidong You +12 more
TL;DR: Findings indicate that NRF2 silencing-mediated reduction of RhoA expression contributes, at least in part, to the poor outcome of breast cancer patients with highNRF2 expression.
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The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies.
TL;DR: In this article, the authors introduce the canonical NLRP3 inflammasome activation pathway and review the cellular/molecular mechanisms of NNBP3 activation by SARS-CoV-2 infection (e.g., viroporins, ion flux and the complement cascade).
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5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress.
TL;DR: DDO-7263 improved the behavioral abnormalities induced by MPTP in mice, significantly attenuated chemically induced dopaminergic neuron loss of tyrosine hydroxylase (TH) in the substantia nigra and striatum of the mouse brain and inhibited the secretion of inflammatory factors.
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Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.
Li-Li Xu,Jun-Feng Zhu,Xiao-Li Xu,Jie Zhu,Li Li,Xi Meiyang,Zheng-Yu Jiang,Ming-Ye Zhang,Fang Liu,Meng-Chen Lu,Qi-Chao Bao,Qi Li,Chao Zhang,Jinlian Wei,Xiaojin Zhang,Lianshan Zhang,Qidong You,Haopeng Sun +17 more
TL;DR: The discovery and optimization of Nrf2 activators with 1,2,4-oxadiazole core provide a new chemotype as NRF2-ARE activators which deserve further optimization with the aim to obtain active anti-inflammatory agents through Nrf 2-ARE pathway.
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2-Substituted 3-methylnaphtho[1,2-b]furan-4,5-diones as novel L-shaped ortho-quinone substrates for NAD(P)H:quinone oxidoreductase (NQO1)
Jinlei Bian,Bang Deng,Li-Li Xu,Xiao-Li Xu,Nan Wang,Tianhan Hu,Zeyu Yao,Jianyao Du,Li Yang,Yonghua Lei,Xiang Li,Haopeng Sun,Xiaojin Zhang,Qidong You +13 more
TL;DR: Determination of superoxide production and in vitro cytotoxicity evaluation in the presence of the NQO1 inhibitor dicoumarol confirmed that the ortho-quinones exerted their antitumor activity through NZO1-mediated ROS production by redox cycling.