Chemodynamic therapy (CDT) uses the tumor microenvironment-assisted intratumoral Fenton reaction for generating highly toxic hydroxyl free radicals (•OH) to achieve selective tumor treatment. However, the limited intratumoral Fenton reaction efficiency restricts the therapeutic efficacy of CDT. Recent years have witnessed the impressive development of various strategies to increase the efficiency of intratumoral Fenton reaction. The introduction of these reinforcement strategies can dramatically improve the treatment efficiency of CDT and further promote the development of enhanced CDT (ECDT)-based multimodal anticancer treatments. In this review, the authors systematically introduce these reinforcement strategies, from their basic working principles, reinforcement mechanisms to their representative clinical applications. Then, ECDT-based multimodal anticancer therapy is discussed, including how to integrate these emerging Fenton reinforcement strategies for accelerating the development of multimodal anticancer therapy, as well as the synergistic mechanisms of ECDT and other treatment methods. Eventually, future direction and challenges of ECDT and ECDT-based multimodal synergistic therapies are elaborated, highlighting the key scientific problems and unsolved technical bottlenecks to facilitate clinical translation.

Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic-Synergized Multimodal Therapy.

Highly efficient microwave-assisted Fenton degradation bisphenol A using iron oxide modified double perovskite intercalated montmorillonite composite nanomaterial as catalyst.

Endogenously activated persulfate by non-thermal plasma for Cu(II)-EDTA decomplexation: Synergistic effect and mechanisms

Treatment of polymer-flooding wastewater by a modified coal fly ash-catalysed Fenton-like process with microwave pre-enhancement: System parameters, kinetics, and proposed mechanism

Xiaoshan Zhang

Papers

Rapid decomplexation of Ni-EDTA by microwave-assisted Fenton reaction