Xiaowen Xue

TL;DR: Triptycene-derived compounds have been prepared to serve as conformational equilibrium reporters for direct measurements of arene-arene interactions in the parallel-displaced orientation and free energies derived from the syn/anti ratios in chloroform range from slightly positive to considerably negative values.

TL;DR: Together, 4c is a novel trihybrid with potent antitumor activity and may be a promising candidate for the treatment of drug-resistant colon cancer.

TL;DR: Triptycenes with C1-MeO/RCOO and C9-XC6H4CH2 have been prepared to determine lone pair-arene interactions in the off-center configuration, and compound 7 in the ester series with X = H and R = CF3 is the only compound that shows a slightly repulsive interaction.

TL;DR: Preliminary anti-cancer mechanistic investigation was performed in terms of the cell cycle arrest and cell apoptosis assays of compound 6l against HCT116 using flow cytometry, and the results suggested that compounds 6l inhibited tumor proliferation through inducing early and late cellular apoptosis in a concentration-dependent manner and causing cell cycle Arrest in the S-phase.

TL;DR: The preliminary results indicated that the oxidation of C-19-hydroxyl group of andrographolide to corresponding carboxyl group and the subsequent esterification of the formed carboxylic acid led to considerable improvement in cytotoxicity against the cancer cells.