Showing papers by "Xiaoyan Jiang published in 2001"

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Journal Article•DOI•

Primitive quiescent leukemic cells from patients with chronic myeloid leukemia spontaneously initiate factor-independent growth in vitro in association with up-regulation of expression of interleukin-3

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Tessa L. Holyoake, Xiaoyan Jiang¹, Xiaoyan Jiang², Heather G. Jørgensen², Heather G. Jørgensen¹, Susan M. Graham¹, Susan M. Graham², Michael J. Alcorn², Michael J. Alcorn¹, Chris Laird¹, Chris Laird², Allen C. Eaves¹, Allen C. Eaves², Connie J. Eaves², Connie J. Eaves¹ - Show less +11 more•Institutions (2)

University of British Columbia¹, BC Cancer Agency²

01 Feb 2001-Blood

TL;DR: It is shown that entry of leukemic (BCR-ABL-expressing) progenitors into a quiescent (G0) state in vivo is highest among the most primitiveLeukemic cell populations, associated with a down-regulation of IL-3 and G-CSF gene expression, and spontaneously reversible in association with up- regulation of IL -3 expression.

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175 citations