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Xiaoyang Wan
Researcher at Huazhong University of Science and Technology
Publications - 26
Citations - 430
Xiaoyang Wan is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Zebrafish & Medicine. The author has an hindex of 10, co-authored 23 publications receiving 287 citations. Previous affiliations of Xiaoyang Wan include Chinese Academy of Sciences & Tongji Medical College.
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Journal ArticleDOI
Mutations in EMP2 Cause Childhood-Onset Nephrotic Syndrome
Heon Yung Gee,Shazia Ashraf,Xiaoyang Wan,Virginia Vega-Warner,Julian Esteve-Rudd,Svjetlana Lovric,Humphrey Fang,Toby W. Hurd,Carolin E. Sadowski,Susan J. Allen,Edgar A. Otto,Emine Korkmaz,Joseph Washburn,Shawn Levy,David S. Williams,Sevcan A. Bakkaloglu,Anna Zolotnitskaya,Fatih Ozaltin,Weibin Zhou,Friedhelm Hildebrandt,Friedhelm Hildebrandt +20 more
TL;DR: EMP2 mutations are identified as causing a recessive Mendelian form of SSNS, and Knockdown of emp2 in zebrafish resulted in pericardial effusion, supporting the pathogenic role of mutated EMP2 in human NS.
Journal ArticleDOI
Non-alcoholic hepatic steatosis attenuates hepatitis B virus replication in an HBV-immunocompetent mouse model.
TL;DR: In an HBV-immunocompetent mouse model, non-alcoholic hepatic steatosis inhibited HBV replication, as indicated by the reduction of HBV DNA andHBV-related antigens.
Journal ArticleDOI
Loss of Epithelial Membrane Protein 2 Aggravates Podocyte Injury via Upregulation of Caveolin-1
TL;DR: Excessive CAV1 is established as a mediator of the predisposition to podocyte injury because of loss of EMP2, suggesting CAV 1 could be a novel therapeutic target in nephrotic syndrome and podocytes injury.
Journal ArticleDOI
GADD45B mediates podocyte injury in zebrafish by activating the ROS-GADD45B-p38 pathway.
Zhaohong Chen,Xiaoyang Wan,Qing Hou,Shaolin Shi,Lei Wang,P Chen,Xiaodong Zhu,Caihong Zeng,W Qin,W Qin,Weibin Zhou,Zhihong Liu +11 more
TL;DR: It is confirmed that GADD45B was significantly upregulated during the early phase of podocyte injury in cultured human podocytes and that podocyte apoptosis induced by TGF-β and puromycin aminonucleoside was aggravated by Gadd45B overexpression but ameliorated by shRNA-mediated GADD 45B knockdown.
Journal ArticleDOI
Acute kidney injury in acute-on-chronic liver failure is different from in decompensated cirrhosis.
Qun-Qun Jiang,Meifang Han,Ke Ma,Guang Chen,Xiaoyang Wan,Semvua B. Kilonzo,Wen-Yu Wu,Yong-Li Wang,Jie You,Qin Ning +9 more
TL;DR: AKI in ACLF patients is more likely associated with structural kidney injury, and is more progressive, with a poorer response to terlipressin treatment and a worse prognosis than that in DC patients.