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Xiaoyang Wang
Researcher at Zhengzhou University
Publications - 189
Citations - 8126
Xiaoyang Wang is an academic researcher from Zhengzhou University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 44, co-authored 146 publications receiving 7110 citations. Previous affiliations of Xiaoyang Wang include Harvard University & University of Gothenburg.
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Journal ArticleDOI
Synergistic Activation of Caspase-3 by m-Calpain after Neonatal Hypoxia-Ischemia A MECHANISM OF “PATHOLOGICAL APOPTOSIS”?
Klas Blomgren,Klas Blomgren,Changlian Zhu,Xiaoyang Wang,Jan-Olof Karlsson,Anna-Lena Leverin,Ben A. Bahr,Carina Mallard,Henrik Hagberg,Henrik Hagberg +9 more
TL;DR: This is the first report to the authors' knowledge suggesting a direct link between the early, excitotoxic, calcium-mediated activation of calpain after cerebral hypoxia-ischemia and the subsequent activation of caspase-3, thus representing a tentative pathway of “pathological apoptosis.”
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The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia.
Changlian Zhu,Xiaoyang Wang,Xiaoyang Wang,Falin Xu,Falin Xu,Ben A. Bahr,Masahiro Shibata,Yasuo Uchiyama,Henrik Hagberg,Henrik Hagberg,Klas Blomgren,Klas Blomgren +11 more
TL;DR: To the authors' knowledge, this is the first report demonstrating developmental regulation of AIF-mediated cell death as well as involvement of autophagy in a model of brain injury.
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Erythropoietin Improved Neurologic Outcomes in Newborns With Hypoxic-Ischemic Encephalopathy
Changlian Zhu,Wenqing Kang,Falin Xu,Xiuyong Cheng,Zhan Zhang,Liting Jia,Ling Ji,Xiaoyan Guo,Hong Xiong,George Simbruner,Klas Blomgren,Klas Blomgren,Xiaoyang Wang +12 more
TL;DR: Repeated, low-dose, recombinant human erythropoietin treatment reduced the risk of disability for infants with moderate HIE, without apparent side effects.
Journal ArticleDOI
Involvement of apoptosis-inducing factor in neuronal death after hypoxia-ischemia in the neonatal rat brain.
Changlian Zhu,Lin Qiu,Lin Qiu,Xiaoyang Wang,Xiaoyang Wang,Ulrika Hallin,Céline Candé,Guido Kroemer,Henrik Hagberg,Henrik Hagberg,Klas Blomgren,Klas Blomgren +11 more
TL;DR: In this article, the authors reported an involvement of AIF in neuronal death induced by cerebral ischemia in 7-day-old rats by ligation of the left carotid artery and hypoxia (7.7% O2) for 55 min.
Journal ArticleDOI
Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia–ischaemia
Changlian Zhu,Falin Xu,Falin Xu,Xiaoyang Wang,Xiaoyang Wang,Masahiro Shibata,Yasuo Uchiyama,Klas Blomgren,Klas Blomgren,Henrik Hagberg,Henrik Hagberg +10 more
TL;DR: The CNS is more resistant to HI in adult females compared with males, whereas no sex differences were found in the extent of injury in neonatal mice, but critical sex‐dependent differences were demonstrated in vivo with regard to cellular, apoptosis‐related mechanisms.