M
Masahiro Shibata
Researcher at Kagoshima University
Publications - 41
Citations - 3246
Masahiro Shibata is an academic researcher from Kagoshima University. The author has contributed to research in topics: Autophagy & Cathepsin D. The author has an hindex of 22, co-authored 39 publications receiving 3063 citations. Previous affiliations of Masahiro Shibata include Osaka University & Juntendo University.
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Journal ArticleDOI
Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury.
Masato Koike,Masahiro Shibata,Masao Tadakoshi,Kunihito Gotoh,Masaaki Komatsu,Masaaki Komatsu,Satoshi Waguri,Nobutaka Kawahara,Keisuke Kuida,Shigekazu Nagata,Eiki Kominami,Keiji Tanaka,Yasuo Uchiyama +12 more
TL;DR: It is shown that Atg7, a gene essential for autophagy induction, is a critical mediator of H/I-induced neuron death and represents an attractive therapeutic target for minimizing the neurological deficits associated with H/ I brain injury.
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The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia.
Changlian Zhu,Xiaoyang Wang,Xiaoyang Wang,Falin Xu,Falin Xu,Ben A. Bahr,Masahiro Shibata,Yasuo Uchiyama,Henrik Hagberg,Henrik Hagberg,Klas Blomgren,Klas Blomgren +11 more
TL;DR: To the authors' knowledge, this is the first report demonstrating developmental regulation of AIF-mediated cell death as well as involvement of autophagy in a model of brain injury.
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Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease).
Masato Koike,Masahiro Shibata,Satoshi Waguri,Kentaro Yoshimura,Isei Tanida,Eiki Kominami,Takahiro Gotow,Christoph Peters,Kurt von Figura,Noboru Mizushima,Paul Saftig,Yasuo Uchiyama +11 more
TL;DR: Evidence is shown for a major involvement of autophagy in the pathogenesis of Batten disease/lysosomal storage disorders and suggests that not only CD-/- but also CB-/-CL-/- mice could be useful animal models for neuronal ceroid-lipofuscinosis/Batten disease.
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Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia–ischaemia
Changlian Zhu,Falin Xu,Falin Xu,Xiaoyang Wang,Xiaoyang Wang,Masahiro Shibata,Yasuo Uchiyama,Klas Blomgren,Klas Blomgren,Henrik Hagberg,Henrik Hagberg +10 more
TL;DR: The CNS is more resistant to HI in adult females compared with males, whereas no sex differences were found in the extent of injury in neonatal mice, but critical sex‐dependent differences were demonstrated in vivo with regard to cellular, apoptosis‐related mechanisms.
Journal ArticleDOI
The MAP1-LC3 conjugation system is involved in lipid droplet formation.
Masahiro Shibata,Kentaro Yoshimura,Norihiko Furuya,Masato Koike,Masato Koike,Takashi Ueno,Masaaki Komatsu,Masaaki Komatsu,Hiroyuki Arai,Keiji Tanaka,Eiki Kominami,Yasuo Uchiyama,Yasuo Uchiyama +12 more
TL;DR: Results indicate that the LC3 conjugation system is critically involved in lipid metabolism via LD formation, and this work shows that under starvation conditions, LDs in addition to autophagosomes were abundantly formed in the cytoplasm of these tissue cells.