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Xin Xu
Researcher at Macquarie University
Publications - 20
Citations - 139
Xin Xu is an academic researcher from Macquarie University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 4, co-authored 5 publications receiving 57 citations.
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Journal ArticleDOI
Positive-feedback, ratiometric biosensor expression improves high-throughput metabolite-producer screening efficiency in yeast.
TL;DR: Positive-feedback, ratiometric transcriptional regulator expression is likely applicable to many other transcription-factor/promoter pairs used in synthetic biology and metabolic engineering for both dynamic regulation and high-throughput screening applications.
Journal ArticleDOI
Evolutionary engineering in Saccharomyces cerevisiae reveals a TRK1-dependent potassium influx mechanism for propionic acid tolerance.
Xin Xu,Thomas C. Williams,Thomas C. Williams,Christina Divne,Isak S. Pretorius,Ian T. Paulsen +5 more
TL;DR: This study has demonstrated the use of ALE as a powerful tool to improve yeast tolerance to PA and demonstrates high-affinity potassium transport as a new principle for improving organic acid tolerance in strain engineering.
Journal ArticleDOI
Photoresponsive endosomal escape enhances gene delivery using liposome–polycation–DNA (LPD) nanovectors
Wenjie Chen,Wei Deng,Wei Deng,Xin Xu,Xiang Zhao,Jenny Nhu Vo,Ayad G. Anwer,Thomas C. Williams,Thomas C. Williams,Haixin Cui,Ewa M. Goldys,Ewa M. Goldys +11 more
TL;DR: It is shown that light-triggered and biocompatible LPDs enable an improved control of efficient gene delivery, which will be beneficial for future gene therapies.
Journal ArticleDOI
A Multicolor-Switchable Fluorescent Lanthanide MOFs Triggered by Anti-cancer Drugs: Multifunctional Platform for Anti-cancer Drug Sensing and Information Anticounterfeiting
TL;DR: A large number of examples of Ln-MOFs can realize both fluorescence sensing and anticounterfeiting capabilities, but very few examples can realize either fluorescence or anti-fluorescence properties.
Journal ArticleDOI
Microdroplet enabled cultivation of single yeast cells correlates with bulk growth and reveals subpopulation phenomena.
Hangrui Liu,Xin Xu,Kai Peng,Kai Peng,Yuxin Zhang,Lianmei Jiang,Thomas C. Williams,Thomas C. Williams,Ian T. Paulsen,James A. Piper,Ming Li +10 more
TL;DR: The use of monodisperse picolitre droplets as bioreactors to cultivate yeast at the single‐cell level offers the prospect of detecting cell‐to‐cell variations in growth and physiology and is expected to be applied for the engineering of yeast to produce value‐added bioproducts.