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Xin Zhang
Researcher at Southern Medical University
Publications - 21
Citations - 320
Xin Zhang is an academic researcher from Southern Medical University. The author has contributed to research in topics: Neuroprotection & Angiostrongylus cantonensis. The author has an hindex of 5, co-authored 20 publications receiving 106 citations.
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Journal ArticleDOI
Preactivation of Notch1 in remote ischemic preconditioning reduces cerebral ischemia-reperfusion injury through crosstalk with the NF-κB pathway
TL;DR: The neuroprotective effect of RIPC against cerebral I/R injury was associated with preactivation of the Notch1 and NF-κB pathways in neurons and significantly improved neurological scores and reduced infarct volume and neuronal apoptosis in rats subjected to I/ R injury.
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Mesenchymal stem cells alleviate the early brain injury of subarachnoid hemorrhage partly by suppression of Notch1-dependent neuroinflammation: involvement of Botch.
Wenchao Liu,Ran Li,Jian Yin,Shenquan Guo,Yunchang Chen,Haiyan Fan,Gancheng Li,Zhenjun Li,Xifeng Li,Xin Zhang,Xuying He,Chuanzhi Duan +11 more
TL;DR: BMSCs treatment alleviated neurobehavioral impairments and the inflammatory response in EBI after SAH; these effects may be attributed to Botch upregulation in brain tissue, which subsequently inhibited the Notch1 signaling pathway.
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Heat shock protein 22 modulates NRF1/TFAM-dependent mitochondrial biogenesis and DRP1-sparked mitochondrial apoptosis through AMPK-PGC1α signaling pathway to alleviate the early brain injury of subarachnoid hemorrhage in rats.
Haiyan Fan,Rui Ding,Wenchao Liu,Xin Zhang,Ran Li,Boyang Wei,Shi-Xing Su,Fa Jin,Chengcong Wei,Xuying He,Xifeng Li,Chuanzhi Duan +11 more
TL;DR: In this article, the authors showed that heat shock protein 22 (hsp22) under conditions of stress is a friendly mediator of mitochondrial homeostasis, oxidative stress and apoptosis, thus accelerating neurological recovery.
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Efficacy and Safety of Low-Dose Tirofiban for Acute Intracranial Atherosclerotic Stenosis Related Occlusion with Residual Stenosis after Endovascular Treatment
Zhizhong Yan,Zhong-Hua Shi,Wang Yuhai,Chunlei Zhang,Jia-Ming Cao,Chun-Long Ding,Mirui Qu,Yunbao Xia,Jin Cai,Xin Zhang,Handong Wang +10 more
TL;DR: In patients with residual stenosis after EVT due to acute ICAS-O, a low-dose of tirofiban is associated with favorable functional outcome and reduced incidence of reocclusion without increasing any ICH and sICH.
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Rupture Risk Assessment for Cerebral Aneurysm Using Interpretable Machine Learning on Multidimensional Data.
Chubin Ou,Jiahui Liu,Yi Qian,Winston Chong,Xin Zhang,Wenchao Liu,Hengxian Su,Nan Zhang,Jianbo Zhang,Chuanzhi Duan,Xuying He +10 more
TL;DR: The Shapley additive explanation (SHAP) analysis was applied to improve the interpretability of the best machine learning model and reveal the reasoning behind the predictions made by the model as mentioned in this paper.