Showing papers by "Xingde Li published in 2002"
14 Jun 2002
TL;DR: The Doppler OCT catheter's ability to simultaneously obtain both structural and functional information makes it a potentially powerful device of cardiovascular imaging.
Abstract: A miniature fiber Doppler imaging catheter for integrated functional and structural optical coherence tomography (OCT) imaging has been developed. The Doppler catheter can be used to map blood flow profile within a vessel as well as image vessel wall structures. The prototype Doppler catheter was demonstrated in measuring the intraluminal velocity profile in a vessel phantom (conduit). A simple mathematical model can be used to estimate the flow profile outside of normal OCT beam penetration. By extending the spatial range of the flow measurements to approximately two times the normal OCT image penetration depth, the total flow rate can then be calculated from the estimated velocity profiles. The measured total flow rate in the vessel phantom obtained from the Doppler imaging catheter correlates well with the calibrated flow values. The Doppler OCT catheter's ability to simultaneously obtain both structural and functional information makes it a potentially powerful device of cardiovascular imaging.
13 citations
TL;DR: Results show that dual-interfering sources outperform single-source techniques for the detection of heterogeneities in terms of fluorophore concentration and lifetime contrast.
Abstract: We report on a quantitative comparison between the single-source and the dual-interfering-source configurations for the detection of fluorescent heterogeneities embedded in a piecewise highly scattering homogeneous fluorescent background. The study is based on simulations with analytical solutions of the frequency-domain fluorescent diffuse photon density waves and practical signal-to-noise ratio considerations. Results show that dual-interfering sources outperform single-source techniques for the detection of heterogeneities in terms of fluorophore concentration and lifetime contrast. To detect the same inhomogeneity, less concentration and lifetime contrast is required with dual-interfering sources.
11 citations
01 Dec 2002
TL;DR: In this paper, the authors present the recent technological development of optical coherence tomography (OCT) and discuss the potential clinical applications of OCT for diagnosing pathological changes in different organs and systems.
Abstract: In this paper we present the recent technological development of optical coherence tomography (OCT). We also discuss the potential clinical applications of OCT for diagnosing pathological changes in different organs and systems.
5 citations
07 Apr 2002
TL;DR: High resolution, in vivo imaging of osteoarthritic cartilage is performed during knee replacement surgery and imaging of the cartilage in an intact knee joint in vitro is demonstrated using a minimally invasive arthroscopic imaging probe.
Abstract: High resolution, in vivo imaging of osteoarthritic cartilage is performed during knee replacement surgery. Imaging of the cartilage in an intact knee joint in vitro is also demonstrated using a minimally invasive arthroscopic imaging probe.
4 citations
16 Jul 2002
TL;DR: Some of the advances demonstrating the potential of OCT for the identification of high risk plaque are outlined, as there is no effective method for accurate monitoring changes in cartilage.
Abstract: In this presentation, the application of optical coherence tomography (OCT) to the prevention of myocardial infarction and early identification of osteoarthritis is discussed. Myocardial infarction or a heart attack is the leading cause of death worldwide. It results from an acute loss of blood flow to a region of the heart resulting in death to that heart tissue. Most heart attacks are caused by small, thin walled lipid filled plaques which can not be detected by currently available imaging technologies. This paper outlines some of the advances demonstrating the potential of OCT for the identification of high risk plaque. Osteoarthritis is a major cause of mobility in the industrialized world. The hallmark of the disease is a degradation of articular cartilage. As new therapeutics have been shown to be effective in animal models, there effectiveness in humans remains unclear as there is no effective method for accurate monitoring changes in cartilage. In the second part of this manuscript, the effectiveness of OCT for monitoring articular cartilage is described.
2 citations
24 May 2002
TL;DR: Preliminary results demonstrate the feasibility of intraoperative OCT imaging in human subjects as well as imaging in a pathology laboratory environment.
Abstract: Summary form only given. In this study, intraoperative imaging was performed to investigate the feasibility of OCT for imaging prostate pathology in vivo as well as to investigate OCT intraoperative imaging in a more general context. A sterilizable hand-held surgical probe was developed and used with a portable OCT system to image in the surgical suite and pathology laboratory. The imaging probe has a 2 cm working distance which allows the surgeon to maneuver the beam within the tight confines of the surgical field. Preliminary results demonstrate the feasibility of intraoperative OCT imaging in human subjects as well as imaging in a pathology laboratory environment.