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XingJia Wang
Researcher at Texas Tech University Health Sciences Center
Publications - 18
Citations - 1563
XingJia Wang is an academic researcher from Texas Tech University Health Sciences Center. The author has contributed to research in topics: Steroidogenic acute regulatory protein & Leydig cell. The author has an hindex of 15, co-authored 18 publications receiving 1482 citations.
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Journal ArticleDOI
Multiple Signaling Pathways Regulating Steroidogenesis and Steroidogenic Acute Regulatory Protein Expression: More Complicated than We Thought
TL;DR: The current understanding of additional signaling pathways and factors capable of regulating/modulating steroid hormone biosynthesis, and in many cases steroidogenic acute regulatory protein expression, are discussed in this review.
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The role of arachidonic acid in steroidogenesis and steroidogenic acute regulatory (StAR) gene and protein expression.
TL;DR: It is indicated that AA and cAMP transduce signals from trophic hormone receptors to the nucleus through two separate pathways and act to co-regulate steroid production and StAR gene expression and indicates that both pathways are required for troPHic hormone-stimulated steroidogenesis.
Journal ArticleDOI
Involvement of multiple transcription factors in the regulation of steroidogenic acute regulatory protein gene expression.
TL;DR: It has become apparent that functional cooperation, interaction, and alteration of different transcription factors are involved in the fine-tuning of the regulatory events associated with StAR gene transcription.
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Effect of truncated forms of the steroidogenic acute regulatory protein on intramitochondrial cholesterol transfer.
XingJia Wang,Zhiming Liu,Sarah Eimerl,Rina Timberg,Aryeh Weiss,Joseph Orly,Douglas M. Stocco +6 more
TL;DR: A direct effect of Star protein on cholesterol transfer to the inner mitochondrial membrane is demonstrated, that StAR need not enter the mitochondria to produce this transfer, and the importance of the C-terminus of StAR in this process is demonstrated.
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Cyclooxygenase-2 regulation of the age-related decline in testosterone biosynthesis.
XingJia Wang,Chwan-Li Shen,Matthew T. Dyson,Sarah Eimerl,Joseph Orly,James C. Hutson,Douglas M. Stocco +6 more
TL;DR: A novel mechanism in male aging involving COX2 is suggested and a potential application of the mechanism to delay the age-related decline in testosterone biosynthesis is suggested.