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Xinhua Yin
Researcher at Harbin Medical University
Publications - 45
Citations - 799
Xinhua Yin is an academic researcher from Harbin Medical University. The author has contributed to research in topics: Vascular smooth muscle & Apoptosis. The author has an hindex of 14, co-authored 45 publications receiving 601 citations.
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Journal ArticleDOI
Activation in M1 but not M2 Macrophages Contributes to Cardiac Remodeling after Myocardial Infarction in Rats: a Critical Role of the Calcium Sensing Receptor/NRLP3 Inflammasome.
Wenxiu Liu,Xin Zhang,Meng Zhao,Xiaohui Zhang,Jinyu Chi,Yue Liu,Fang Lin,Yu Fu,Dandan Ma,Xinhua Yin +9 more
TL;DR: It is suggested that the CaSR/NLRP3 inflammasome plays an essential role via the PLC-IP3 pathway in M1MΦ to promote cardiac remodeling post-MI in rats, including accelerated cardiac fibroblast phenotypic transversion, increased collagen and extracellular matrix (ECM) secretion.
Journal ArticleDOI
Inhibition of endoplasm reticulum stress by ghrelin protects against ischemia/reperfusion injury in rat heart.
Gai-gai Zhang,Xu Teng,Yue Liu,Yan Cai,Ye-Bo Zhou,Xiao-Hui Duan,Jun-Qiu Song,Yi Shi,Chaoshu Tang,Chaoshu Tang,Xinhua Yin,Yong-Fen Qi,Yong-Fen Qi +12 more
TL;DR: Preadministration of ghrelin in vivo greatly ameliorated the damaged heart function, attenuated myocardial injury and apoptosis, and decreased the expression of ERS markers: it decreased the mRNA and protein levels of glucose-regulated protein78 (GRP78) and C/EBP homologous protein (CHOP), with reduced caspase-12 protein expression.
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Cortistatin protects myocardium from endoplasmic reticulum stress induced apoptosis during sepsis
TL;DR: Results for the first time showed the previously unexpected role of CST to directly protect myocardial from apoptosis through inhibiting ERS and partly through GHS-R1a.
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H3 Relaxin Protects Against Myocardial Injury in Experimental Diabetic Cardiomyopathy by Inhibiting Myocardial Apoptosis, Fibrosis and Inflammation.
Xiaohui Zhang,Liya Pan,Kelaier Yang,Yu Fu,Yue Liu,Jinyu Chi,Xin Zhang,Siting Hong,Xiao Ma,Xinhua Yin +9 more
TL;DR: This study is the first to demonstrate that H3 relaxin plays an anti-apoptotic, anti-fibrotic and anti-inflammatory role in DCM.
Journal ArticleDOI
Ghrelin protects heart against ERS-induced injury and apoptosis by activating AMP-activated protein kinase
Gaigai Zhang,Huai-Qiu Cai,Yan-Hui Li,Yu-Bin Sui,Jin-Sheng Zhang,Jin-Rui Chang,Ming Ning,Yang Wu,Chaoshu Tang,Yong-Fen Qi,Xinhua Yin +10 more
TL;DR: In conclusion, ghrelin could protect heart against ERS-induced injury and apoptosis, at least partially through a GHS-R1a/CaMKK/AMPK pathway.