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Xuemei Tong
Researcher at University of Pennsylvania
Publications - 8
Citations - 946
Xuemei Tong is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Medicine & Glycolysis. The author has an hindex of 4, co-authored 4 publications receiving 830 citations. Previous affiliations of Xuemei Tong include Shanghai Jiao Tong University.
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Journal ArticleDOI
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
Jiangbin Ye,Anthony A. Mancuso,Xuemei Tong,Patrick S. Ward,Patrick S. Ward,Jing Fan,Joshua D. Rabinowitz,Craig B. Thompson +7 more
TL;DR: It is suggested that tumor cells use serine-dependent regulation of PKM2 and GCN2 to modulate the flux of glycolytic intermediates in support of cell proliferation.
Journal ArticleDOI
The molecular determinants of de novo nucleotide biosynthesis in cancer cells
TL;DR: This review will focus on recent progress in understanding how glucose and glutamine metabolism is redirected by oncogenes in order to support de novo nucleotide biosynthesis during proliferation and how metabolic reprogramming can be potentially exploited in the development of new cancer therapies.
Journal ArticleDOI
Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1alpha-induced metabolic reprograming.
Fangping Zhao,Anthony A. Mancuso,Thi Bui,Xuemei Tong,Joshua J. Gruber,Cezary R. Swider,Patricia V. Sanchez,Julian J. Lum,Nabil Sayed,Junia V. Melo,Alexander E. Perl,Martin Carroll,Stephen W. Tuttle,Craig B. Thompson +13 more
TL;DR: In both primary cultures of cells from patients exhibiting blast transformation and in vivo xenograft tumors, use of oxythiamine, which can inhibit both the pyruvate dehydrogenase complex and transketolase, resulted in enhanced imatinib sensitivity of tumor cells.
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The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation
TL;DR: It is demonstrated that the expression of ChREBP can be induced in response to mitogenic stimulation and that the induction of Ch REBP is required for efficient cell proliferation, and that suppression ofChREBP led to a p53-dependent reduction in tumor growth.
Journal ArticleDOI
Sirtuin5 protects colorectal cancer from DNA damage by keeping nucleotide availability
Hao-Lian Wang,Yan Chen,Yun-Qian Wang,En-Wei Tao,Juan Tan,Qianqian Liu,Chun-Min Li,Xuemei Tong,Qin Yan Gao,Jie Hong,Ying-Xuan Chen,Jingyun Fang +11 more
TL;DR: In this article , SIRT5 knockdown impairs the production of ribose-5-phosphate, which is essential for nucleotide synthesis, resulting in continuous and irreparable DNA damage and consequently leading to cell cycle arrest and enhanced apoptosis.