A short and efficient synthesis of cinnoline-fused cyclic enediyne is reported. Richter cyclization of o-(1,3-butadiynyl)phenyltriazene produced 3-alkynyl-4-bromocinnoline. The Sonogashira coupling of the latter with 5-hexyn-1-ol was employed for the introduction of a second acetylenic moiety. The crucial cyclization step was achieved under Nozaki–Hiyama–Kishi conditions. Cinnoline-fused 10-membered ring enediyne is more reactive than corresponding carbocyclic analog and produces good yield of the Bergman cyclization product upon mild heating. This enediyne induces single-strand dDNA scissions upon incubation at 40 °C.

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Synthesis and reactivity of cinnoline-fused cyclic enediyne.

This invention relates to novel compounds having the structural formula I below: 
and their pharmaceutically acceptable salts, tautomers or in vivo-hydrolysable precursors, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of anxiety disorders, cognitive disorders, and/or mood disorders.

Compounds and uses thereof

The l,2-bis(sulphapyridyl)oxamide ligand [L] and its complexes with FeIII, CoII, CuII and ZnII chloride were synthesized and characterized by elemental analyses, i.r., n.m.r., e.p.r. and u.v.–vis. spectroscopy and molar conductance measurements. Spectroscopic studies show that all the complexes are octahedral and covalent. The electrochemical behaviour of the CoII complex was monitored by cyclic voltammetry in a buffer/DMF solution (95:5). The E
0 values −0.622 and −0.502 V reveal a reversible one electron redox wave attributed to a CoII/CoI redox couple at a scan rate of 0.1 V s−1. The interaction of the CoII complex with bovine milk casein (BMC) was studied at the same scan rate, which reveals a strong binding as the E
0 values shift to more negative potential (E
0 = −0.908 and −0.703 V). The cyclic voltammograms of the CoII complex bound by BMC were recorded at different pH's. The plot of E
0
versus pH showed that E
0 values are maximal at pH 7.4 indicating good interaction between the BMC and the CoII complex which is further confirmed by kinetic data. The kinetic studies of the CoII complex bound to BMC was monitored in phosphate buffer solution at different pH's by spectrophotometry. The absorbance changes were monitored at 278 nm (λ
max for BMC) with respect to time and pseudo-first-order rate constants, K
obs, were obtained from the slope and intercept of the straight line using the least squares regression method. The plot of absorbance versus time at different pH's was linear up to 80% completion of the reaction. The pH-rate profile data reveals that the reactions are pH dependent.

New metal compounds and their reactivity towards bovine milk casein

New complexes of the stoichiometries M(L1)22H2O, M(L2)22H2O [M = Co, Ni, Cu, Fe; L1 = 4-aminocinnolin-3-carboxylic acid and L2 = 4-amino-6-fluoro-7-chlorocinnolin-3-carboxylic acid] have been synthesized and characterized by elemental analyses, magnetic moments, thermal studies, electronic, IR and EPR spectral studies. On the basis of the generated data probable structures have been proposed. Referee I: M. Athar Referee II: N. K. Kaushik

Synthesis and Characterization of 4-Aminocinnolin-3-Carboxylic Acid and 4-Amino-6-Fluoro-7-Chloro-Cinnolin-3-Carboxylic Acid Complexes with Cobalt (II), Nickel (II), Copper (II) and Iron (II)

Y. N. Manohara

Papers

Synthesis and Characterization of 4-Aminocinnolin-3-Carboxylic Acid and 4-Amino-6-Fluoro-7-Chloro-Cinnolin-3-Carboxylic Acid Complexes with Cobalt (II), Nickel (II), Copper (II) and Iron (II)