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Yan Lin
Researcher at Fourth Military Medical University
Publications - 8
Citations - 128
Yan Lin is an academic researcher from Fourth Military Medical University. The author has contributed to research in topics: Macrophage & Notch signaling pathway. The author has an hindex of 3, co-authored 8 publications receiving 59 citations.
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Journal ArticleDOI
Notch Signaling Modulates Macrophage Polarization and Phagocytosis Through Direct Suppression of Signal Regulatory Protein α Expression.
Yan Lin,Jun-Long Zhao,Qi-Jun Zheng,Xun Jiang,Jiao Tian,Shi-Qian Liang,Hong-Wei Guo,Hong-Yan Qin,Ying-Min Liang,Hua Han +9 more
TL;DR: It is validated that Notch activation could repress SIRPα expression likely via the Hes family co-repressors and further validated SirPα as a target for tumor therapy through modulating macrophage polarization and phagocytosis.
Journal ArticleDOI
The modified endoscopic retrograde appendicitis therapy versus antibiotic therapy alone for acute uncomplicated appendicitis in children
Jian-Qin Kang,Wei Zhang,Lingchao Zeng,Yan Lin,Junqing Wu,Nini Zhang,Xiaomin Xie,Yu Zhang,Xiangzeng Liu,Baoxi Wang,Ruijing Yang,Xun Jiang +11 more
TL;DR: In this article, a prospective, randomized control clinical trial was conducted to compare the modified endoscopic retrograde appendicitis therapy (mERAT) to antibiotic therapy in children with AUA.
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Astragaloside IV Alleviates the Experimental DSS-Induced Colitis by Remodeling Macrophage Polarization Through STAT Signaling.
Lianlian Tian,Jun-Long Zhao,Jian-Qin Kang,Shibo Guo,Nini Zhang,Lei Shang,Ya-Long Zhang,Jian Zhang,Xun Jiang,Yan Lin +9 more
TL;DR: Wang et al. as mentioned in this paper found that Astragaloside IV attenuated clinical activity of DSS-induced colitis that mimics human IBD and resulted in the phenotypic transition of macrophages from immature pro-inflammatory macrophage to mature pro-resolving macophages.
Journal ArticleDOI
Soluble extracellular domains of human SIRPα and CD47 expressed in Escherichia coli enhances the phagocytosis of leukemia cells by macrophages in vitro.
Yan Lin,Xue-Qian Yan,Fang Yang,Xin-Wei Yang,Xun Jiang,Xing-Cheng Zhao,Bing-Ke Zhu,Li Liu,Hong-Yan Qin,Ying-Min Liang,Hua Han +10 more
TL;DR: In vitro phagocytosis assay showed that the soluble Trx-hSIRP(ext) and TrX-CD47( Ext) polypeptides could be alternative molecules to interrupt CD47-SirPα interaction between leukemia cells and macrophages, and might be potentially useful for the targeted therapy of leukemia.
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Metagenomic Analysis Identified Stenotrophomonas maltophilia Pneumonia in an Infant Suffering From Unexplained Very Severe Pneumonia.
TL;DR: Next-generation sequencing technology and a metagenomic approach were applied to detect and characterize respiratory bactiera in an UP case in infant and Stenotrophomonas maltophilia was the only bacterial pathogen detected in blood.