H
Hua Han
Researcher at Fourth Military Medical University
Publications - 141
Citations - 6663
Hua Han is an academic researcher from Fourth Military Medical University. The author has contributed to research in topics: Notch signaling pathway & Cellular differentiation. The author has an hindex of 39, co-authored 141 publications receiving 5754 citations. Previous affiliations of Hua Han include Kyoto University.
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Journal ArticleDOI
Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision
Hua Han,Kenji Tanigaki,Norio Yamamoto,Kazuki Kuroda,Momoko Yoshimoto,Tatsutoshi Nakahata,Koichi Ikuta,Tasuku Honjo +7 more
TL;DR: It is suggested that RBP-J, probably by mediating Notch signaling, controls T versus B cell fate decision in lymphoid progenitors.
Journal ArticleDOI
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells.
Kenji Tanigaki,Hua Han,Norio Yamamoto,Kei Tashiro,Masaya Ikegawa,Kazuki Kuroda,Akira Suzuki,Toru Nakano,Tasuku Honjo +8 more
TL;DR: In mice with RBP-J–deficient B cells, had no obvious changes in immunoglobulin production in response to Ficoll, lipopolysaccharide or chicken gammaglobulin, which indicates that MZB cells play pivotal roles in the clearance of these bacteria.
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Notch signaling determines the M1 versus M2 polarization of macrophages in antitumor immune responses.
Yao-Chun Wang,Fei He,Fan Feng,Xiao-Wei Liu,Guang-Ying Dong,Hong-Yan Qin,Xing-Bin Hu,Min-Hua Zheng,Liang Liang,Lei Feng,Ying-Min Liang,Hua Han +11 more
TL;DR: It is shown that the M2-like tumor-associated macrophages (TAM) have a lower level of Notch pathway activation in mouse tumor models, and RBP-J-mediated Notch signaling regulates the M1 versus M2 polarization through SOCS3.
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Regulation of αβ/γδ T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling
Kenji Tanigaki,Masayuki Tsuji,Norio Yamamoto,Hua Han,Jun Tsukada,Hiromasa Inoue,Masato Kubo,Tasuku Honjo +7 more
TL;DR: It is demonstrated that Notch/RBP-J signaling regulates γδ T cell generation and migration, αβ T cell maturation, terminal differentiation of CD4 + T cells into Th1/Th2 cells, and activation of T cells.
Journal ArticleDOI
Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway.
Kazuki Kuroda,Hua Han,Shoichi Tani,Kenji Tanigaki,Tin Tun,Takahisa Furukawa,Yoshihito Taniguchi,Hisanori Kurooka,Yoshio Hamada,Shinya Toyokuni,Tasuku Honjo +10 more
TL;DR: Results indicate that high levels of MINT negatively regulate Notch signaling and block differentiation of precursor B cells into marginal zone B cells, and may serve as a functional homolog of Drosophila Hairless.