Y
Yan Wang
Researcher at Capital Medical University
Publications - 26
Citations - 510
Yan Wang is an academic researcher from Capital Medical University. The author has contributed to research in topics: Inflammation & Proinflammatory cytokine. The author has an hindex of 9, co-authored 21 publications receiving 299 citations.
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Journal ArticleDOI
Astilbin inhibits Th17 cell differentiation and ameliorates imiquimod-induced psoriasis-like skin lesions in BALB/c mice via Jak3/Stat3 signaling pathway.
TL;DR: In vitro, astilbin inhibited Th17 cell differentiation and IL-17 secretion of isolated T cells, and inhibited Jak/Stat3 signaling in Th17 cells, while up-regulating Stat3 inhibitor SCOSE3 expression in psoriatic lesions, likely alleviates psoriasis-like skin lesions by inhibiting Th17 related inflammation.
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Paeoniflorin inhibits imiquimod-induced psoriasis in mice by regulating Th17 cell response and cytokine secretion.
TL;DR: Results suggest that PF inhibits IMQ-induced psoriasis by regulating Th17 cell response and cytokine secretion via phosphorylation of Stat3.
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Paeonol ameliorates imiquimod-induced psoriasis-like skin lesions in BALB/c mice by inhibiting the maturation and activation of dendritic cells
Yujiao Meng,Mingxing Wang,Xiangjiang Xie,Tingting Di,Jingxia Zhao,Yan Lin,Xiaolong Xu,Ningfei Li,Yating Zhai,Yan Wang,Ping Li +10 more
TL;DR: Results indicate that paeonol suppresses the maturation and activation of DCs by decreasing MyD88 and TLR8 proteins in the TLR7/8 signaling pathway which finally alleviates psoriasis-like skin lesions.
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MicroRNA-29b Mediates Lung Mesenchymal-Epithelial Transition and Prevents Lung Fibrosis in the Silicosis Model.
Jingping Sun,Qiuyue Li,Ximeng Lian,Zhonghui Zhu,Xiaowei Chen,Wanying Pei,Siling Li,Ali Abbas,Yan Wang,Lin Tian +9 more
TL;DR: It is demonstrated that miR-29b acted as a novel negative regulator of silicosis fibrosis-inhibited lung fibrosis, probably by promoting MET and by suppressing EMT in the lung.
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Exosomes derived from three-dimensional cultured human umbilical cord mesenchymal stem cells ameliorate pulmonary fibrosis in a mouse silicosis model
Chunjie Xu,Jing Zhao,Qiuyue Li,Lin Hou,Yan Wang,Siling Li,Fuyang Jiang,Zhonghui Zhu,Lin Tian +8 more
TL;DR: Two studies support a potential role for hucMSC-Exos in ameliorating pulmonary fibrosis and provide new evidence for improving clinical treatment induced by silica.