Y
Yan Zhen
Researcher at Southern Medical University
Publications - 15
Citations - 970
Yan Zhen is an academic researcher from Southern Medical University. The author has contributed to research in topics: Cell cycle & Cell growth. The author has an hindex of 13, co-authored 15 publications receiving 838 citations. Previous affiliations of Yan Zhen include Guangzhou Medical University.
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Journal ArticleDOI
Alpha-enolase promotes cell glycolysis, growth, migration, and invasion in non-small cell lung cancer through FAK-mediated PI3K/AKT pathway
Qiaofen Fu,Yan Liu,Yue Fan,Shengni Hua,Hong-Ying Qu,Su-Wei Dong,Ruilei Li,Mengyang Zhao,Yan Zhen,Xiaoli Yu,Yiyu Chen,Rongcheng Luo,Rong Li,Libo Li,Xiaojie Deng,Weiyi Fang,Zhen Liu,Zhen Liu,Xin Song,Xin Song +19 more
TL;DR: Overexpressed ENO1 significantly elevated NSCLC cell glycolysis, proliferation, clone formation, migration, and invasion in vitro, as well as tumorigenesis and metastasis in vivo by regulating the expression of glycoleysis, cell cycle, and epithelial-mesenchymal transition (EMT)-associated genes.
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ZEB2 Mediates Multiple Pathways Regulating Cell Proliferation, Migration, Invasion, and Apoptosis in Glioma
Songtao Qi,Ye Song,Yuping Peng,Hao Wang,Hao Long,Xiaoli Yu,Zhiyong Li,Lu-xiong Fang,Aibing Wu,Weiren Luo,Yan Zhen,Ying Zhou,Yan Chen,Chunping Mai,Zhen Liu,Weiyi Fang +15 more
TL;DR: Overexpression of ZEB2 is an unfavorable factor that may facilitate glioma progression and is positively correlated with pathology grade classification of gliomas patients.
Journal ArticleDOI
Tumor suppressor PDCD4 modulates miR-184- mediated direct suppression of C-MYC and BCL2 blocking cell growth and survival in nasopharyngeal carcinoma
Yan Zhen,Zhen Liu,Zhen Liu,Huiling Yang,Huiling Yang,Xiaoli Yu,Qiangyun Wu,Shengni Hua,Xiaobin Long,Qingping Jiang,Ye-Qiong Song,Chao Cheng,Hao Hao Wang,M Zhao,Qiaofen Fu,Xiaoming Lyu,Yiyu Chen,Yue-Qin Fan,Yan Liu,Xin Li,Weiyi Fang +20 more
TL;DR: These studies are the first to demonstrate that PDCD4 as tumor suppressor regulated miR-184-mediated direct targeting of BCL2 and C-MYC via PI3K/AKT and JNK/C-Jun pathway attenuating cell proliferation and survival in NPC.
Journal ArticleDOI
miR-374a-CCND1-pPI3K/AKT-c-JUN feedback loop modulated by PDCD4 suppresses cell growth, metastasis, and sensitizes nasopharyngeal carcinoma to cisplatin.
Yan Zhen,Weiyi Fang,M Zhao,Rongcheng Luo,Youtan Liu,Qiaofen Fu,Yuyao Chen,Chao Cheng,Y Zhang,Zhongqiu Liu,Zhongqiu Liu +10 more
TL;DR: These studies are the first to demonstrate that the miR-374a-CCND1-pPI3K/AKT-c-JUN feedback loop induced by PDCD4 supresses NPC cell growth, metastasis and chemotherapy resistance.
Journal ArticleDOI
Elevated expression of CDK4 in lung cancer
Aibing Wu,Bin Wu,Jinsong Guo,Weiren Luo,Dong Wu,Huiling Yang,Yan Zhen,Xiaoli Yu,Hao Wang,Ying Zhou,Zhen Liu,Weiyi Fang,Zhixiong Yang +12 more
TL;DR: Overexpressed CDK4 is a potential unfavorable prognostic factor and mediates cell cycle progression by regulating the expression of p21 in lung cancer.