Yang Yu

TL;DR: It is demonstrated that SiNPs could induce oxidative stress, inflammation, and NO/NOS system imbalance, and eventually lead to endothelial dysfunction via activation of the MAPK/Nrf2 pathway and nuclear factor-κB signaling.

TL;DR: Exposure to silica nanoparticles is suggested to be a possible risk factor to cardiovascular system through its effects on the expression of cardiovascular-related proteins in embryos by western blot analysis.

TL;DR: The data indicated that the toxic effect mechanisms of silica nanoparticles on endothelial cells was through DNA damage response (DDR) via Chk1-dependent G2/M checkpoint signaling pathway, suggesting that exposure to silicas nanoparticles could be a potential hazards for the development of cardiovascular diseases.

TL;DR: It is demonstrated that SiNPs triggered autophagy and apoptosis via ROS-mediated MAPK/Bcl-2 and PI3K/Akt/mTOR signaling in endothelial cells, and subsequently disturbed the endothelial homeostasis and impaired endothelium.

TL;DR: It is demonstrated that Nano-SiO2 could disturb the NO/NOS system, induce inflammatory response, activate autophagy, and eventually lead to endothelial dysfunction via the PI3K/Akt/mTOR pathway, indicating that exposure to Nano- SiO2 is a potential risk factor for cardiovascular diseases.