Showing papers in "Biomaterials in 2013"

TL;DR: Among the new strategies, the use of phages or of antisense peptide nucleic acids are discussed, as well as the possibility to modulate the local immune response by active cytokines, to contrast the establishment of an implant infection.

TL;DR: This review paper highlights the recent exciting developments in dual and multi-stimuli responsive polymeric nanoparticles for precision drug delivery applications, with a particular focus on their design, drug release performance, and therapeutic benefits.

TL;DR: Current and potential future use of biologic coatings for orthopaedic implants to facilitate osseointegration and mitigate possible adverse tissue responses including the foreign body reaction and implant infection are reviewed.

TL;DR: In this paper, a copper-containing mesoporous bioactive glass (Cu-MBG) scaffolds with interconnective large pores (several hundred micrometer) and well-ordered mesopore channels (around 5 nm) were used to develop multifunctional bioactive scaffolds, which combine angiogenesis capacity, osteostimulation, and antibacterial properties for regenerating lost bone tissues.

TL;DR: The feasibility of fabricating complex heterogeneous tissue constructs containing multiple cell types using inkjet printing technology is demonstrated and the bioprinted constructs were able to survive and mature into functional tissues with adequate vascularization in vivo.

TL;DR: Highly advanced levels of hESC-CM maturation after 2 weeks of 3D cardiac patch culture are demonstrated and carry important implications for future drug development and cell therapy studies.

TL;DR: Biodegradable Cur-M-H composite might have great application for wound healing because of its well tissue adhesiveness and ability to release curcumin in an extended period.

TL;DR: The role of EGfr in cancer, different types of EGFR inhibitors, preclinical and clinical status of EG FR inhibitors as well as summarized the recent efforts made in the field of molecular EGFR targeting are outlined.

TL;DR: Mouse esophageal tumor growth was found to be significantly inhibited by the photothermal effect of Fe3O4 nanoparticles, resulting in effective tumor reduction, and a morphological examination revealed that after a photothermal therapy, the tumor tissue structure exhibited discontinuation, the cells were significantly shriveled and some cells have finally disintegrated.

TL;DR: The results show that the pore size of a scaffold is a more critical regulator of the BMMΦ polarization compared to the fiber diameter, and shows a potential role for MyD88 in regulating M1 B MMΦ signaling on the large vs. small fiber/pore size PDO scaffold.

TL;DR: This work sought to systematically investigate in vivo biodistribution and potential toxicity of as-made GO and a number of polyethylene glycol (PEG) functionalized GO derivatives with different sizes and surface coatings, after oral and intraperitoneal administration at high doses.

TL;DR: The synthesis of tansferrin-conjugated SeNPs and its use as a cancer-targeted drug delivery system to achieve enhanced cellular uptake and anticancer efficacy is described.

TL;DR: This work prepared polymeric nanoparticles densely coated with low molecular weight polyethylene glycol to minimize muco-adhesion, and compared their transport to that of uncoated particles in human respiratory mucus, which was collected from the endotracheal tubes of surgical patients with no respiratory comorbidities.

TL;DR: The results of this study suggest that the mixed micelles (DSPE-PEG(2000)/DSPe-Peg(3400)-2C5/PHIS-P EG(2000)) could enhance the tumor cell-specific internalization and trigger the quick drug release, resulting in the improved anti-cancer efficacy.

TL;DR: The histological analyses revealed the RADA(16)-IKVAV self-assembling peptide hydrogel not only enhanced survival of encapsulated NSCs but also reduced the formation of glial astrocytes and the improvement in brain tissue regeneration after 6 weeks post-transplantation.

TL;DR: Compared with chemotherapy or photothermal treatment alone, the combined treatment showed a synergistic effect, resulting in higher therapeutic efficacy, and the lower systematic toxicity of GNRs@mSiO(2) has been validated.

TL;DR: Benefiting from the unique multifunctional hybrid nanostructure, UCNPs-NGO/ZnPc nanocomposites developed herein are promising as an integrated theranostic probe for potential UCL image-guided combinatorial PDT/PTT of cancer.

TL;DR: This work shows the potential of nanoGO for synergistic combination phototherapy of tumor in vivo through the combined action of photodynamic and photothermal effects.

TL;DR: The resulted HF-IR-780 NPs are a potential theranostic agent for imaging-guided cancer therapy and show good monodispersity, significant stability, and excellent molecular targeting to folate receptor over-expressing MCF-7 cells.

TL;DR: MNP-MSN-PLGA-Tf NPs are promising carriers for the delivery of dual drugs for effective treatment of brain glioma and could be enhanced by the presence of magnetic field and the usage of Tf as targeting ligand.

TL;DR: The HA based nanosystems portend to be promising siRNA delivery vectors for systemic targeting of CD44 overexpressing cancers including tumor initiating (stem-) cells and metastatic lesions.

TL;DR: In vivo photothermal ablation of tumor with excellent treatment efficacy was achieved and the concept of developing polyaniline-based nanoparticles can serve as a platform technology for the next generation of in vivo PTT agents.

TL;DR: The development of a visible light-based PSL system (VL-PSL), using lithium phenyl-2,4,6-trimethylbenzoylphosphinate as the initiator and polyethylene glycol diacrylate (PEGDA) as the monomer, to produce hydrogel scaffolds with specific shapes and internal architectures.

TL;DR: A systematic investigation of the absorption, distribution, excretion and toxicity of silica nanoparticles with the average size of 110 nm after four different exposure routes including intravenous, hypodermic, intramuscular injection and oral administration to mice showed that a fraction of the SNs administrated by the intramuuscular and hypODermic injection could cross different biological barriers into the liver but with a low absorption rate.

TL;DR: A controlled release of an antimicrobial peptide (AMP) from titanium surface through a non-cytotoxic multilayered coating can be a potential approach to locally deliver AMPs to prevent peri-implant infection in orthopaedics without being toxic to host cells.

TL;DR: It is reported here that Au NPs can catalyze the rapid decomposition of hydrogen peroxide and mimic SOD and catalase mimetics, and it is found that, mimicking SOD, AuNPs efficiently catalyzeThe decompositionof superoxide.

TL;DR: In vivo experiments revealed that SrCS dramatically stimulated bone regeneration and angiogenesis in a critical sized OVX calvarial defect model, and the enhanced bone regeneration might be attributed to the modulation of osteogenic differentiation of endogenous mesenchymal stem cells (MSCs) and the inhibition of osteoclastogenesis, accompanying with the promotion of the angiogenic activity of endothelial cells (ECs).

TL;DR: The results reveal that the pre-osteoblast functions, bone growth, and apatite formation on the SPEEK surfaces are affected by many factors, including positive effects introduced by the 3D porous structure and SO3H groups as well as negative ones due to the low pH environment.

TL;DR: Topical application of water soluble cerium oxide nanoparticles (Nanoceria) accelerates the healing of full-thickness dermal wounds in mice by a mechanism that involves enhancement of the proliferation and migration of fibroblasts, keratinocytes and VECs.

TL;DR: Results suggest that the developed Sr-HT coatings have the potential for future use as coatings for orthopedic/dental and maxillofacial devices.