Yanling Wang

TL;DR: This unique ability of norepinephrine to increase cell number in an apparently mitogenically dormant tissue provides possibilities to augment the metabolic capacity of brown adipose tissue, also for therapeutic purposes.

TL;DR: It is found that LPA could induce Erk1/2 activation, and this implies that in non-transformed systems, RTK transactivation may not be involved in the mediation of GPCR-induced Erk 1/2 MAP kinase activation.

TL;DR: It is demonstrated that, in contrast to other systems where the mitogenic effect of cAMP requires the synergistic action of (serum) growth factors, especially insulin/IGF, the cAMP effect in brown preadipocytes was independent of serum and insulin.

TL;DR: In this article, the EGF receptor kinase inhibitor AG1478 had no significant effect on EGF-induced Erk1/2 activation induced by any of these adrenergic agonists.

TL;DR: Norepinephrine, through the second messenger cAMP, stimulates cell prolif- eration in a variety of cell types including brown preadipocytes, however, the cell signalling pathway mediating the cAMP pathway is unclear.