Yaowared Sumanont

TL;DR: The neuropharmacological tests in mice supported the idea that the SOD mimicking complexes were able to penetrate to the brain as well as their role in the modulation of brain neurotransmitters under the aberrant conditions, and manganese complexes seem to be the most promising neuroprotective agents for vascular dementia.

TL;DR: Curcumin manganese complex and AcylCpCpx show greater NO radical scavenging than their parent compounds, curcumin and acetylcurcumin, respectively, however, the IC(50) values of curCumin and related compounds were found to be less than astaxanthin, an extreme antioxidant, with the lower IC( 50) value.

TL;DR: It is suggested that Cp-Mn and DiAc-Cp- Mn have an advantage to be neuroprotective agents in the treatment of acute brain pathologies associated with NO-induced neurotoxicity and oxidative stress-induced neuronal damage such as epilepsy, stroke and traumatic brain injury.

TL;DR: It is likely that in addition to radical scavenging and SOD-like activities, the suppression of potential neuronal injury marker expression by Cp-Mn and DiAc-Cp-mn, contributes to the neuroprotective activities of these compounds, which are superior to those of curcumin, on KA-induced excitotoxicity in the hippocampus.

TL;DR: The results supported the brain delivery and the role of manganese in SOD activity as well as in the modulation of brain neurotransmitters in the aberrant condition.