YashoNandini Singh

TL;DR: This study synthesized for the first time a MUC1-derived positional scanning synthetic glycopeptide combinatorial library (PS-SGCL) that vary in number and location of cancer-associated Tn antigen using the “tea bag” approach and revealed a carbohydrate density-dependent affinity trend and site-specific glycosylation requirements for high affinity binding to these lectins.

TL;DR: A method for large-scale expression of Gal-1 and its histidine-tagged analog for use in binding studies by isothermal titration calorimetry (ITC) and development of an analytical method based on AlphaScreen technology to screen forGal-1 inhibitors are developed.

TL;DR: In this paper, the authors showed that O-glycosylation of Tyr681 can induce a conformational change in APP and affect its proteolytic processing fate toward the amyloidogenic pathway.

TL;DR: The results confirm that the Swedish mutation and/or O-glycosylation can render APP model glycopeptides more susceptible to cleavage by β-secretase and sheds new light on the possible role of glycosolation and/ or glycan density on the rate of Aβ40 aggregation.

TL;DR: Alanine scan analogues of odorranalectin, a cyclic peptide that exhibits lectin like properties, were screened for binding BSA-conjugated monosaccharides using an enzyme-linked lectin assay (ELLA), and results revealed that Lys5, Phe7, Tyr9, Gly12, Leu14, and Thr17 were crucial for bindingBSA-L-fucose, BSA