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Yasuhiro Otomo
Researcher at Sysmex Corporation
Publications - 23
Citations - 641
Yasuhiro Otomo is an academic researcher from Sysmex Corporation. The author has contributed to research in topics: Metastasis & Lymph node. The author has an hindex of 8, co-authored 23 publications receiving 577 citations.
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Journal ArticleDOI
One-step Nucleic Acid Amplification for Intraoperative Detection of Lymph Node Metastasis in Breast Cancer Patients
Masahiko Tsujimoto,Kadzuki Nakabayashi,Katsuhide Yoshidome,Tomoyo Kaneko,Takuji Iwase,Futoshi Akiyama,Yo Kato,Hitoshi Tsuda,Shigeto Ueda,Kazuhiko Sato,Yasuhiro Tamaki,Shinzaburo Noguchi,Tatsuki R. Kataoka,Hiromu Nakajima,Yoshifumi Komoike,Hideo Inaji,Koichiro Tsugawa,Koyu Suzuki,Seigo Nakamura,Motonari Daitoh,Yasuhiro Otomo,Nariaki Matsuura +21 more
TL;DR: Clinical results indicate that the OSNA assay provides a useful intraoperative detection method of lymph node metastasis in breast cancer patients, and results similar to those of three-level histopathology.
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One-Step Nucleic Acid Amplification (OSNA) for the Application of Sentinel Node Concept in Gastric Cancer
Yoshihisa Yaguchi,Hidekazu Sugasawa,Hironori Tsujimoto,Hideki Takata,Kadzuki Nakabayashi,Takashi Ichikura,Satoshi Ono,Shuichi Hiraki,Naoko Sakamoto,Takuya Horio,Isao Kumano,Yasuhiro Otomo,Hidetaka Mochizuki,Junji Yamamoto,Kazuo Hase +14 more
TL;DR: The OSNA method is feasible and acceptable for detecting LN metastases in patients with Gastric cancer and should be applied for the intraoperative diagnosis in the SN-navigation surgery in gastric cancer.
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An accurate and rapid detection of lymph node metastasis in non-small cell lung cancer patients based on one-step nucleic acid amplification assay.
Masayoshi Inoue,Kayo Hiyama,Kadzuki Nakabayashi,Eiichi Morii,Masato Minami,Noriyoshi Sawabata,Yasushi Shintani,Tomoyuki Nakagiri,Yoshiyuki Susaki,Jun Maeda,Masahiko Higashiyama,Jiro Okami,Yuichiro Yoshida,Junyi Ding,Yasuhiro Otomo,Meinoshin Okumura +15 more
TL;DR: An OSNA assay using CK19 could be effective for molecular diagnosis of lymph node metastasis in lung cancer, the first report suggesting the potential clinical utility of one-step nucleic acid amplification (OSNA) assay for intraoperative rapid diagnosis of nodal status in Lung cancer.
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Combination analysis of a whole lymph node by one-step nucleic acid amplification and histology for intraoperative detection of micrometastasis.
Kiyomi Taniyama,Junichi Motoshita,Junichi Sakane,Kyoko Makita,Yasumasa Akai,Motonari Daito,Yasuhiro Otomo,Hiroshi Ono,Tomoya Mizunoe,Yukiyasu Takeuchi,Harumi Tominaga,Masato Koseki +11 more
TL;DR: A combined analysis of LN by HE and OSNA could increase the sensitivity for detecting micrometastasis during surgery.
Journal ArticleDOI
An Optimal mRNA Marker for OSNA (One-step Nucleic Acid Amplification) Based Lymph Node Metastasis Detection in Colorectal Cancer Patients
Noriko Yamamoto,Motonari Daito,Kayo Hiyama,Junyi Ding,Kadzuki Nakabayashi,Yasuhiro Otomo,Masahiko Tsujimoto,Nariaki Matsuura,Yo Kato +8 more
TL;DR: CK19 mRNA has the best diagnostic performance and its cut-off value for discriminating positive from negative lymph nodes can be set in the range of 75-500 copies/µl with 96.4% sensitivity and 100% specificity.