Masahiko Higashiyama

TL;DR: Sublobar resection should be considered as an alternative for stage IA non-small cell lung cancers 2 cm or less, even in low-risk patients, and could lay the foundation for starting randomized controlled trials anew.

TL;DR: It is suggested that PFAA profiling has great potential for improving cancer screening and diagnosis and understanding disease pathogenesis, which involves a relatively simple plasma assay and imposes a lower physical burden on subjects when compared to existing screening methods.

TL;DR: Segmentectomy with regional lymph node dissection, including the mediastinum, should be considered as an acceptable alternative treatment for selected patients with T1 N0 M0 disease.

TL;DR: The major advantage of BEAMing is its ability to calculate the fraction of T790M-positive alleles from the alleles with activating mutations, regardless of normal cell DNA contamination, which may be useful for monitoring disease progression.

TL;DR: In this paper, the authors conducted 220 deep-phenotype genome-wide association studies (diseases, biomarkers and medication usage) in BioBank Japan (n = 179,000), by incorporating past medical history and text-mining of electronic medical records.