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Yi-Chung Pan
Researcher at Kaohsiung Medical University
Publications - 4
Citations - 640
Yi-Chung Pan is an academic researcher from Kaohsiung Medical University. The author has contributed to research in topics: Angiogenesis & Extracellular vesicle. The author has an hindex of 4, co-authored 4 publications receiving 429 citations.
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Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1.
Hsu Yl,Jen-Yu Hung,Wei-An Chang,Yi-Shiuan Lin,Yi-Chung Pan,Pei-Hsun Tsai,Cheng-Ying Wu,Po-Lin Kuo,Po-Lin Kuo +8 more
TL;DR: The study reveals the clinical relevance and prognostic value of cancer-derived exosomal miR-23a under hypoxic conditions, and investigates a unique intercellular communication, mediated by cancer- derived exosomes, which modulates tumour vasculature.
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Hypoxic Lung-Cancer-Derived Extracellular Vesicle MicroRNA-103a Increases the Oncogenic Effects of Macrophages by Targeting PTEN
Ya-Ling Hsu,Jen-Yu Hung,Wei-An Chang,Shu-Fang Jian,Yi-Shiuan Lin,Yi-Chung Pan,Cheng-Ying Wu,Po-Lin Kuo,Po-Lin Kuo +8 more
TL;DR: The results delineate a novel mechanism by which lung cancer cells induce immunosuppressive and pro-tumoral macrophages through EVs and inspire further research into the clinical application of EV inhibition or PTEN restoration for immunotherapy.
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CXCL17-derived CD11b+Gr-1+ myeloid-derived suppressor cells contribute to lung metastasis of breast cancer through platelet-derived growth factor-BB
Ya-Ling Hsu,Meng-Chi Yen,Wei-An Chang,Pei-Hsun Tsai,Yi-Chung Pan,Ssu-Hui Liao,Po-Lin Kuo,Po-Lin Kuo +7 more
TL;DR: It is demonstrated that breast cancer cells secrete CXCL17, which increases the accumulation of CD11b+Gr-1+ MDSCs in the lungs, and that patients with high levels of CxCL17 have shorter distant metastasis-free and overall survival rates, indicators of poor prognosis.
Journal ArticleDOI
Bone-marrow-derived cell-released extracellular vesicle miR-92a regulates hepatic pre-metastatic niche in lung cancer.
Ya-Ling Hsu,Ming-Shyan Huang,Jen-Yu Hung,Wei-An Chang,Ying-Ming Tsai,Yi-Chung Pan,Yi-Shiuan Lin,Hung-Pei Tsai,Po-Lin Kuo,Po-Lin Kuo +9 more
TL;DR: The sequential steps of liver PMN formation in lung cancer are revealed, providing critical mediators that prepare PMN in the liver, and new targets are identified that offer valuable options for diagnosis and therapeutic intervention.