Yi Fu Guan

TL;DR: Justicia gendarussa, a medicinal plant collected in Vietnam, was identified as a potent anti-HIV-1 active lead from the evaluation of over 4500 plant extracts and it was determined that the presence of a quinovopyranosyloxy group in the structure is likely essential to retain the high degree of anti-hIV activity of this type of compounds.

TL;DR: In a search for new anti-HIV active leads from over several thousands of plant extracts, a potent plant lead is identified as Justicia gendarussa (Acanthaceae), a medicinal plant that has been used for the treatment of injury, arthritis and rheumatism in Asia.

TL;DR: 15 derivatives of the CHCl3 extract of the leaves and stems of the medicinal plant Ardisia gigantifolia led to the isolation of two anti‐TB 5‐alkylresorcinols, and the distinct structure–activity correlations of the parent compound were elucidated based on these derivatives.

TL;DR: It is revealed that the antiproliferative properties of miliusanes in carcinoma cells were highly associated with the p21-dependent induction of cellular senescence, which is superior to the mainstay chemotherapeutics paclitaxel or fluorouracil.

TL;DR: In this article, a bioassay-directed fractionation of the roots of Radermachera boniana Dop (Bignoniaceae) led to the isolation of 17 naphthalene-based quinones and related derivatives including radermacherones A (1), B (2) and C (6), radermaquinone (3), and radermacherol (5).