Yihui Guan

TL;DR: A review of recent advances in the development of neuroinflammation imaging tracers and an outlook for promising targets in the future can be found in this article, where the authors provided an outlook of promising targets for brain imaging.

TL;DR: In vivo experiments and in vitro experiments indicated that Dcf1 deletion mediates neuroinflammation and induces dysfunction of activated microglia, preventing migration and the execution of phagocytosis, and support further investigation into the biological mechanisms underlying microglial-related neuroinflammatory diseases, and the role of DCF1 in the immune response.

TL;DR: The findings support further investigation of age-dependent changes in expression of DAT, VMAT2, and glucose metabolism for their potential use as a new imaging biomarker for study of brain development and functional maturation.

TL;DR: In this article, the authors found that SV2A deficiency leads to a simultaneous increase in Aβ and Tau hyperphosphorylation, while SV 2A overexpression was associated with downregulation of β-site APP cleaving enzyme 1 and apolipoprotein E genes.

TL;DR: Comparison of microarray data between advanced-age mice treated with human umbilical cord blood plasma protein and the phosphate-buffered saline control showed that the genes that contribute to the revitalization of advanced- age mice are different from the genes induced by aging, implying that the revitalizations of advanced -age mice is not a simple reverse process of normal aging progression.