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Yingchong Wang
Researcher at Wuhan University
Publications - 11
Citations - 362
Yingchong Wang is an academic researcher from Wuhan University. The author has contributed to research in topics: Inflammasome & Innate immune system. The author has an hindex of 4, co-authored 10 publications receiving 187 citations.
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Journal ArticleDOI
Zika virus infection induces host inflammatory responses by facilitating NLRP3 inflammasome assembly and interleukin-1β secretion
Wenbiao Wang,Geng Li,De Wu,Zhen Luo,Pan Pan,Mingfu Tian,Yingchong Wang,Feng Xiao,Aixin Li,Kailang Wu,Xiaohong Liu,Lang Rao,Fang Liu,Yingle Liu,Yingle Liu,Jianguo Wu,Jianguo Wu +16 more
TL;DR: It is revealed that the polymerase of Zika virus binds NLRP3 to facilitate inflammasome complex assembly and induce production of IL-1β in human macrophages, human PBMCs and mice, resulting in pathogenesis in mice.
Journal ArticleDOI
STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection.
Wenbiao Wang,Dingwen Hu,Caifeng Wu,Yuqian Feng,Aixin Li,Weiyong Liu,Yingchong Wang,Keli Chen,Mingfu Tian,Feng Xiao,Qi Zhang,Muhammad Adnan Shereen,Weijie Chen,Pan Pan,Pin Wan,Kailang Wu,Jianguo Wu,Jianguo Wu +17 more
TL;DR: It is demonstrated that the cGAS-STING-NLRP3 signaling is essential for host defense against HSV-1 infection.
Journal ArticleDOI
A Biomimetic Nanodecoy Traps Zika Virus To Prevent Viral Infection and Fetal Microcephaly Development
Lang Rao,Wenbiao Wang,Wenbiao Wang,Qian-Fang Meng,Mingfu Tian,Bo Cai,Yingchong Wang,Aixin Li,Minghui Zan,Feng Xiao,Lin-Lin Bu,Geng Li,Andrew Li,Yingle Liu,Shishang Guo,Xingzhong Zhao,Tza-Huei Wang,Wei Liu,Jianguo Wu,Jianguo Wu +19 more
TL;DR: It is demonstrated that NDs significantly attenuate the ZikV-induced inflammatory responses and degenerative changes and thus improve the survival rate of ZIKV-challenged mice, and successfully prevent ZIKVs from passing through physiologic barriers into the fetal brain and thereby mitigate ZIKv-induced fetal microcephaly in pregnant mice.
Journal ArticleDOI
Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome
Wenbiao Wang,Wenbiao Wang,Dingwen Hu,Yuqian Feng,Caifeng Wu,Yunting Song,Weiyong Liu,Aixin Li,Yingchong Wang,Keli Chen,Mingfu Tian,Feng Xiao,Qi Zhang,Weijie Chen,Pan Pan,Pin Wan,Yingle Liu,Yingle Liu,Hui-Yao Lan,Kailang Wu,Jianguo Wu,Jianguo Wu +21 more
TL;DR: Paxillin plays key roles in ATP-induced activation of the P2X7 receptor and NLRP3 inflammasome by facilitating the formation of the BMDMs and BMDCs as well as in human PBMCs and THP-1-differentiated macrophages.
Journal ArticleDOI
NS5 Conservative Site Is Required for Zika Virus to Restrict the RIG-I Signaling.
Aixin Li,Wenbiao Wang,Yingchong Wang,Keli Chen,Feng Xiao,Dingwen Hu,Lixia Hui,Weiyong Liu,Yuqian Feng,Geng Li,Tan Qiuping,Yingle Liu,Kailang Wu,Jianguo Wu,Jianguo Wu +14 more
TL;DR: An essential role of NS5 conservative site D146 in ZikV-mediated repression of innate immune system is uncovered, a distinct mechanism by which ZIKV evades host immune responses is illustrated, and a potential target for anti-viral infection is discovered.