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Yingjie Guo
Researcher at Jilin University
Publications - 45
Citations - 1701
Yingjie Guo is an academic researcher from Jilin University. The author has contributed to research in topics: Drug delivery & Pancreatic cancer. The author has an hindex of 18, co-authored 43 publications receiving 1499 citations. Previous affiliations of Yingjie Guo include Chinese Academy of Sciences.
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pH-Triggered Controlled Drug Release from Mesoporous Silica Nanoparticles via Intracelluar Dissolution of ZnO Nanolids
TL;DR: It is anticipated that these nanoparticles may prove to be a significant step toward the development of a pH-sensitive drug delivery system that minimizes drug toxicity.
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Mechanism of CYP2C9 inhibition by flavones and flavonols.
TL;DR: Flavonoids can participate in interactions with drugs that act as substrates for CYP2C9 and provide a possible molecular basis for understanding cooperativity in human P450-mediated drug-drug interactions.
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Acid degradable ZnO quantum dots as a platform for targeted delivery of an anticancer drug
Faheem Muhammad,Mingyi Guo,Yingjie Guo,Wenxiu Qi,Fengyu Qu,Fuxing Sun,Huijun Zhao,Guangshan Zhu +7 more
TL;DR: This approach provides a valuable ZnO QDs-based nanovector that can simultaneously realize targeting, diagnosis, and therapy of cancer cells as validated by a drug release profile, confocal microscopy and a cell-cytotoxicity assay.
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Identification of a novel variant CYP2C9 allele in Chinese.
TL;DR: A novel CYP2C9 allele involving a T269C transversion in exon 2 that leads to a Leu90Pro substitution in the encoded protein was correlated with reduced plasma clearance of drugs that are substrates for CYP 2C9.
Journal ArticleDOI
Role of CYP2C9 and its variants (CYP2C9*3 and CYP2C9*13) in the metabolism of lornoxicam in humans.
Yingjie Guo,Yifan Zhang,Ying Wang,Xiaoyan Chen,Dayong Si,Dafang Zhong,J. Paul Fawcett,Hui Zhou +7 more
TL;DR: Si et al. as mentioned in this paper identified a new CYP2C9 allele with a Leu90Pro mutation in a Chinese poor metabolizer of lornoxicam, which occurs in approximately 2% of the Chinese population.