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Yinxiang Wei

Researcher at Henan University

Publications -  21
Citations -  487

Yinxiang Wei is an academic researcher from Henan University. The author has contributed to research in topics: Internal medicine & Apoptosis. The author has an hindex of 10, co-authored 17 publications receiving 360 citations. Previous affiliations of Yinxiang Wei include Academy of Military Medical Sciences & Zhejiang University.

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A novel IL-23p19/Ebi3 (IL-39) cytokine mediates inflammation in Lupus-like mice.

TL;DR: The results show that IL‐39 might contribute to immunopathogenic mechanisms of systemic lupus erythematosus, and could be used as a possible target for its treatment.
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Gypenosides improve diabetic cardiomyopathy by inhibiting ROS-mediated NLRP3 inflammasome activation.

TL;DR: It is found that high glucose (HG) induced myocardial damage by activating the NLRP3 inflammasome and then promoting IL‐1β and IL‐18 secretion in H9C2 cells and NRVMs and that Gps may be potential and effective drugs for DCM via the inhibition of ROS‐mediated NLRP2 inflam Masome activation.
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Exosomes with membrane-associated TGF-β1 from gene-modified dendritic cells inhibit murine EAE independently of MHC restriction.

TL;DR: The results indicate that mTGF‐β1‐EXOs possess powerful immunosuppressive ability and can effectively inhibit the development and progression of EAE in different strains of mice.
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New Use for an Old Drug: Inhibiting ABCG2 with Sorafenib

TL;DR: This study finds the new use for sorafenib, which has a dual-mode action by inducing ABCG2 degradation in lysosome in addition to inhibiting its function, and forms impressive alignment with the pharmacophore hypothesis, supporting the argument that sorafinib is a potentialABCG2 inhibitor.
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Activated cytotoxic lymphocytes promote tumor progression by increasing the ability of 3LL tumor cells to mediate MDSC chemoattraction via Fas signaling.

TL;DR: It is found that CTLs induced tumor cells to secrete PGE2 and increase tumor cell-mediated chemoattraction of MDSCs via Fas signaling, which was favorable to tumor growth.