Yiu-Fai Chen

TL;DR: The BHR is discussed as a model for determining the triggers responsible for environmentally-induced hypertension, and plasma norepinephrine determinations revealed a significant response to cold stress in all groups, but only in WKY.

TL;DR: The results suggest that the pressor action of LY171555 in conscious rats is dependent on activation of sympathetic outflow and AVP release through the central D2 dopaminergic system and that the central pressor effects of Ly 171555 could mask a depressor effect of L y1715 55 at the peripheral D2 dopamine receptor.

TL;DR: The results suggest that the depressor action of i.v. administered bromocriptine is mediated mainly through a central dopaminergic mechanism rather than by peripheral effects and that plasma EP responses to bromOCriptine do not directly contribute to its depressoraction.

TL;DR: It is suggested that LY171555 decreases MAP and heart rate in anesthetized rats by inhibiting norepinephrine release from nerve endings through the peripheral dopamine D2 receptor and that the time course of the depressor response may be altered by LY 171555-induced AVP release, the magnitude of which appears to be dependent on the anesthetic agent.

TL;DR: The results suggest that the pressor action of LY171555 in conscious LE rats is mediated by an increase in plasma AVP and by activation of sympathetic outflow through the central D2 dopaminergic system but not through thecentral vasopressinergic system.