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Yiu Wa Kwan
Researcher at The Chinese University of Hong Kong
Publications - 132
Citations - 3544
Yiu Wa Kwan is an academic researcher from The Chinese University of Hong Kong. The author has contributed to research in topics: Endothelium & Angiogenesis. The author has an hindex of 32, co-authored 126 publications receiving 3093 citations. Previous affiliations of Yiu Wa Kwan include University of Rochester & University of Strathclyde.
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Inhibition of human equilibrative nucleoside transporters by 4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-6-imino-N-(naphthalen-2-yl)-1,3,5-triazin-2-amine.
Philip Chiu Tsun Tang,Cui Yang,Rachel Wai Sum Li,Simon Ming-Yuen Lee,Maggie Pui Man Hoi,Shun Wan Chan,Yiu Wa Kwan,Chung Ming Tse,George P.H. Leung +8 more
TL;DR: It is concluded that the novel compound 4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-6-imino-N-(naphthalen-2-yl)-1,3,5-triazin -2-amine (FPMINT) inhibits ENTs in an irreversible and non-competitive manner.
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Modulatory effect of interleukin-1β on rat isolated basilar artery contraction
TL;DR: The data suggest that IL-1beta causes an enhancement of U46619-mediated basilar artery contraction that probably involves TTX-sensitive neuronal release of an alpha1-adrenoceptor agonist and activation of p42/p44 and p38 mitogen-activated protein kinases/p21(ras) pathways.
Journal Article
Inhibition by extracellular ATP of L-type calcium channel currents in guinea-pig single sinoatrial nodal cells: involvement of protein kinase C.
Yiu Wa Kwan,A.-D. Qi +1 more
TL;DR: The present study investigated the effect of extracellular ATP on L-type calcium channel currents of guinea-pig single sinoatrial nodal cells by using the whole cell patch clamp technique, and found that activation of protein kinase C involves activation of adenosine, the catabolic product of ATP, which is a cardiodepressant.
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Presynaptic modulation by L-glutamate and GABA of sympathetic co-transmission in rat isolated vas deferens.
TL;DR: It is concluded that the excitatory amino acid L‐glutamate modulates the electrically evoked vas deferens contraction through conversion to the inhibitory amino acid GABA by a specific GABA transaminase.
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Lactobacillus casei Strain Shirota Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice by Increasing Taurine-Conjugated Bile Acids and Inhibiting NF-κB Signaling via Stabilization of IκBα
Wing Yan Wong,Brandon Dow Chan,Tung-Ting Sham,Magnolia Muk-Lan Lee,Chi-On Chan,Chung-Ting Chau,Daniel K. W. Mok,Yiu Wa Kwan,William Chi-Shing Tai +8 more
TL;DR: The therapeutic effects of LcS are demonstrated in DSS-induced colitis, providing new insights into its effect on bile acid metabolism and the related anti-inflammatory mechanisms, and provide support for the application of LCS in the treatment of IBD.