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Yoko Hieda
Researcher at Hennepin County Medical Center
Publications - 9
Citations - 741
Yoko Hieda is an academic researcher from Hennepin County Medical Center. The author has contributed to research in topics: Nicotine & Biological activity. The author has an hindex of 8, co-authored 9 publications receiving 731 citations.
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Journal ArticleDOI
A Nicotine Conjugate Vaccine Reduces Nicotine Distribution to Brain and Attenuates Its Behavioral and Cardiovascular Effects in Rats
Paul R. Pentel,David H. Malin,Sofiane Ennifar,Yoko Hieda,Dan E. Keyler,J.Ronald Lake,Judit R Milstein,Lisa Basham,R.Todd Coy,J.William D Moon,Robert B. Naso,Ali Ibrahim Fattom +11 more
TL;DR: It is demonstrated that the administration of nicotine-specific antibodies can reduce or prevent some of the pharmacokinetic, cardiovascular, and behavioral consequences of nicotine in rats.
Journal ArticleDOI
Immunization of rats reduces nicotine distribution to brain
TL;DR: It is demonstrated that nicotine-specific antibodies produced by active immunization rapidly bind nicotine in arterial blood, reduce the unbound nicotine concentration, and reduce the early distribution of nicotine to brain in anesthetized rats.
Journal ArticleDOI
Vaccination against nicotine during continued nicotine administration in rats: immunogenicity of the vaccine and effects on nicotine distribution to brain.
TL;DR: The data suggest that vaccination during concurrent nicotine administration is feasible, and that the ability of vaccination to reduce nicotine distribution to brain is preserved even after months of nicotine dosing at rates approximating cigarette smoking.
Journal ArticleDOI
High-level secretion of two antibody single chain Fv fragments by Pichia pastoris
Patrick Eldin,Mary E. Pauza,Yoko Hieda,Gaofeng Lin,Michael P. Murtaugh,Paul R. Pentel,Christopher A. Pennell +6 more
TL;DR: Soluble sFv fragments were purified from culture supernatants in one step by affinity or metal-chelating chromatography, and were indistinguishable from their bacterially expressed counterparts in terms of affinity.
Journal ArticleDOI
Effects of a nicotine conjugate vaccine on the acquisition and maintenance of nicotine self-administration in rats.
Mark G. LeSage,Daniel E. Keyler,Yoko Hieda,Gregory T. Collins,Danielle Burroughs,Chap T. Le,Paul R. Pentel +6 more
TL;DR: Data suggest that vaccination against nicotine can reduce the reinforcing effects of nicotine in rats and may have therapeutic potential for the treatment of tobacco dependence.