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Yonatan B Tzur
Researcher at Hebrew University of Jerusalem
Publications - 26
Citations - 1702
Yonatan B Tzur is an academic researcher from Hebrew University of Jerusalem. The author has contributed to research in topics: Caenorhabditis elegans & Gene. The author has an hindex of 10, co-authored 21 publications receiving 1512 citations. Previous affiliations of Yonatan B Tzur include Harvard University.
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Journal ArticleDOI
Heritable genome editing in C. elegans via a CRISPR-Cas9 system.
Ari E. Friedland,Yonatan B Tzur,Kevin M. Esvelt,Monica P. Colaiácovo,George M. Church,George M. Church,John A. Calarco +6 more
TL;DR: The use of clustered, regularly interspaced, short palindromic repeats (CRISPR)-associated endonuclease Cas9 to target genomic sequences in the Caenorhabditis elegans germ line using single-guide RNAs that are expressed from a U6 small nuclear RNA promoter is reported.
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SUN-domain proteins: 'Velcro' that links the nucleoskeleton to the cytoskeleton.
TL;DR: It is proposed that SUN-domain proteins connect cytoplasmic and nucleoplasmic activities, by serving both as mechanical adaptors and nuclear envelope receptors, to physically connect the nucleus to every major component of the cytoskeleton.
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Heritable Custom Genomic Modifications in Caenorhabditis elegans via a CRISPR-Cas9 System
Yonatan B Tzur,Ari E. Friedland,Saravanapriah Nadarajan,George M. Church,George M. Church,John A. Calarco,Monica P. Colaiácovo +6 more
TL;DR: The CRISPR–Cas9 system was adapted for template-mediated repair of targeted double-strand breaks via homologous recombination in Caenorhabditis elegans, enabling customized and efficient genome editing.
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Specific and conserved sequences in D. melanogaster and C. elegans lamins and histone H2A mediate the attachment of lamins to chromosomes.
TL;DR: Results suggest that specific residues in lamin Dm0 and histone H2A mediate the attachment of the nuclear lamina to chromosomes in vivo, which could have implications on the understanding of laminopathic diseases.
Journal ArticleDOI
Transmission electron microscope studies of the nuclear envelope in Caenorhabditis elegans embryos
Merav Cohen,Yonatan B Tzur,Esther Neufeld,Naomi Feinstein,Michael Delannoy,Katherine L. Wilson,Yosef Gruenbaum +6 more
TL;DR: Results show evolutionarily conserved protein localization, interactions, and functions of the C. elegans nuclear envelope as visualized by characteristic changes in nuclear architecture including condensation of chromatin, clustering of NPCs, membrane blebbing, and the presence of vesicles inside the nucleus.