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Yong-Jun Liu
Researcher at University of Birmingham
Publications - 13
Citations - 3884
Yong-Jun Liu is an academic researcher from University of Birmingham. The author has contributed to research in topics: Antigen & Germinal center. The author has an hindex of 12, co-authored 13 publications receiving 3847 citations.
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Journal ArticleDOI
Mechanism of antigen-driven selection in germinal centres.
Yong-Jun Liu,Douglas E. Joshua,Gwyn T. Williams,Christopher A. Smith,John Gordon,I. C. M. Maclennan +5 more
TL;DR: It is found that, on culture, centrocytes isolated from human tonsil kill themselves within a few hours by apoptosis, not a feature of other tonsillar B cells.
Journal ArticleDOI
Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens.
TL;DR: Blast cells in S phase were identified in tissue sections by staining cells which had been pulse labeled in vivo with 5‐bromo‐2′‐deoxyuridine and B blasts was distinguished from the strong cytoplasmic hapten binding by specific plasma cells and plasmablasts.
Journal ArticleDOI
Germinal center cells express bcl-2 protein after activation by signals which prevent their entry into apoptosis.
Yong-Jun Liu,David Y. Mason,David Y. Mason,Gerald D. Johnson,Gerald D. Johnson,Sandra D. Abbot,Sandra D. Abbot,Christopher D. Gregory,Christopher D. Gregory,Debbie L. Hardie,Debbie L. Hardie,John Gordon,John Gordon,Ian C. M. MacLennan +13 more
TL;DR: Dual‐fluorescence studies on small lymphocytes confirm the presence of bcl‐2 protein in mitochondria but show that this is also present in other extra‐nuclear areas.
Journal ArticleDOI
Germinal centres in T-cell-dependent antibody responses.
TL;DR: For more than a century follicles have been recognized as a site of intense cell proliferation and cell death, but the significance of this activity is beginning to emerge: antigen-driven B-cell proliferation, somatic mutation, positive and negative selection, and memory and plasma cell development all appear to take place within the follicle.
Journal ArticleDOI
Recombinant 25‐kDa CD23 and interleukin 1α promote the survival of germinal center B cells: evidence for bifurcation in the development of centrocytes rescued from apoptosis
Yong-Jun Liu,Jennifer A. Cairns,Michelle J. Holder,Sandra D. Abbot,Katherin U. Jansen,Jean-Yves Bonnefoy,John R. Gordon,Ian C. M. MacLennan +7 more
TL;DR: A functional rationale to the high level expression of CD23 found within a discrete subset of FDC is provided and a bifurcation in the development of germinal center B cells following their rescue from apoptosis is indicated.