Yong Wang

TL;DR: Detailed planning, strategy, and methods for tracheal intubation in COVID-19 patients are proposed, which create a risk to physiologically compromised patients and to attending healthcare providers.

TL;DR: Dantrolene, a known antagonist of the RYP and a clinically available drug to treat malignant hyperthermia, can ameliorate the abnormal Ca2+ release from the RYR in AD and the subsequent pathogenesis, such as increased β- secretase and γ-secretase activities, production of Amyloid-β 42 and its oligomer, impaired autophagy, synapse dysfunction, and memory loss.

TL;DR: In this article, the authors investigated the effectiveness of several drugs on shivering prevention and treatment during cesarean sections (CSs) under neuraxial anesthesia (NA) and concluded that appropriate use of dexmedetomidine, fentanyl, sufentanil, ketamine, meperidine, tramadol and MgSO4 may effectively reduce the incidence and severity of shivering during CSs under NA, while trials on the effect of intravenous ondansetron reached inconclusive results.

TL;DR: This review focuses on the relationship between the altered RyR expression and function and the pathogenesis of AD, and the potential application of dantrolene as a novel treatment for the disease.

TL;DR: Dantrolene ameliorated the impairment of neurogenesis and synaptogenesis, in association with restoring intracellular Ca2+ homeostasis and physiologic autophagy, cell survival, and proliferation in induced pluripotent stem cells and their derived neurons from sporadic and familial Alzheimer’s disease patients.