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Yong-Xing Zhou
Researcher at National Institutes of Health
Publications - 8
Citations - 425
Yong-Xing Zhou is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Spinocerebellar ataxia & Trinucleotide repeat expansion. The author has an hindex of 8, co-authored 8 publications receiving 410 citations.
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Fibroblast Growth Factor Receptor-1 is Required for Long-Term Potentiation, Memory Consolidation, and Neurogenesis
TL;DR: This study suggests a critical role of FGFR1 in adult neurogenesis in vivo, provides a potential link between proliferative neuroGenesis and dentate LTP, and raises the possibility that adult Neurogenesis might contribute to memory consolidation.
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Lack of Huntingtin-Associated Protein-1 Causes Neuronal Death Resembling Hypothalamic Degeneration in Huntington's Disease
TL;DR: It is shown that huntingtin-associated protein-1 (HAP1), which is involved in intracellular trafficking of epidermal growth factor receptor (EGFR), is highly expressed in the hypothalamus and may contribute to the hypothalamic neurodegeneration and loss of body weight in HD.
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The shortest expanded allele of the MJD1 gene in a Chinese MJD kindred with autonomic dysfunction.
TL;DR: The high clinical pleomorphism and the phenomenon with the 51-CAG-repeat units caused the disease phenotype in the authors' patient, but the normal phenotype in the individuals from another MJD family strongly supports that the MJD phenotype is modulated by modifier factors.
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Machado-Joseph disease in four Chinese pedigrees: Molecular analysis of 15 patients including two juvenile cases and clinical correlations
Yong-Xing Zhou,Yoshihisa Takiyama,Shuichi Igarashi,Y. F. Li,B. Y. Zhou,D. C. Gui,K. Endo,H. Tanaka,Z. H. Chen,L. S. Zhou,M. Z. Fan,B. X. Yang,Jean Weissenbach,G. X. Wang,Shoji Tsuji +14 more
TL;DR: A significant negative correlation between the age of onset of symptoms and (CAG)n array size was found and the intergenerational increase in number of CAG repeat units was associated with the clinical phenomenon of anticipation.
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Molecular and Clinical Study of Spinocerebellar Ataxia Type 7 in Chinese Kindreds
TL;DR: Clinical study revealed that great variation occurred in the age of onset, initial symptoms, and associated signs of spinocerebellar ataxia, and intergenerational instability of the array was associated with the clinical phenomenon of anticipation.