Yongbiao Li

TL;DR: A peptidomics platform that couples magnetics-based, automated solid-phase extraction of small peptides with a high-resolution MALDI-TOF mass spectrometric readout is developed and it is found that sera from thyroid cancer patients can be distinguished from healthy controls based on an array of 98 discriminant peptides.

TL;DR: The results demonstrate the feasibility of confocal mosaicing microscopy toward rapid surgical pathology to potentially expedite and guide surgery and both large and small tumors are detectable.

TL;DR: Comparison of mosaics to histology shows that nodular, micronodular, and superficial BCCs are easily detected, however, infiltrative and sclerosing BCCs tend to be obscured within the surrounding bright dermis.

TL;DR: Ex vivo three-dimensional collagen-fibrin gel cultures of dissociated B16 melanoma tumors recapitulated the in vivo suppression of antimelanoma immunity, rendering the dissociated tumor cells resistant to killing by cocultured activated, antigen-specific T cells.

TL;DR: Confocal mosaicing presently requires 9 min, instead of 20–45 min per excision for preparing frozen histology, and thus may provide a means for rapid pathology‐at‐the‐bedside to expedite and guide surgery.