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Yonggang Zhou
Researcher at University of Science and Technology of China
Publications - 35
Citations - 3935
Yonggang Zhou is an academic researcher from University of Science and Technology of China. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 12, co-authored 19 publications receiving 2884 citations. Previous affiliations of Yonggang Zhou include Inner Mongolia University.
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Journal ArticleDOI
Effective treatment of severe COVID-19 patients with tocilizumab.
Xiaoling Xu,Mingfeng Han,Tiantian Li,Wei Sun,Dongsheng Wang,Binqing Fu,Yonggang Zhou,Xiaohu Zheng,Yun Yang,Xiuyong Li,Xiaohua Zhang,Aijun Pan,Haiming Wei +12 more
TL;DR: Preliminary data show that tocilizumab, which improved the clinical outcome immediately in severe and critical COVID-19 patients, is an effective treatment to reduce mortality.
Journal ArticleDOI
Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients
Yonggang Zhou,Binqing Fu,Xiaohu Zheng,Dongsheng Wang,Changcheng Zhao,Yingjie Qi,Rui Sun,Zhigang Tian,Xiaoling Xu,Haiming Wei +9 more
TL;DR: The results demonstrate that excessive non-effective host immune responses by pathogenic T cells and inflammatory monocytes may associate with severe lung pathology and suggest that monoclonal antibodies targeting GM-CSF or interleukin 6 may be effective in blocking inflammatory storms and, therefore, be a promising treatment of severe COVID-19 patients.
Posted ContentDOI
Aberrant pathogenic GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe pulmonary syndrome patients of a new coronavirus
Yonggang Zhou,Binqing Fu,Xiaohu Zheng,Dongsheng Wang,Changcheng Zhao,Yingjie Qi,Rui Sun,Zhigang Tian,Xiaoling Xu,Haiming Wei +9 more
TL;DR: The results demonstrate that excessive non-effective host immune responses by pathogenic T cells and inflammatory monocytes may associate with severe lung pathology and suggest that monoclonal antibody that targets the GM-CSF or interleukin 6 receptor may potentially curb immunopathology caused by 2019-nCoV and consequently win more time for virus clearance.
Journal ArticleDOI
Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors
Binqing Fu,Yonggang Zhou,Xiang Ni,Xianhong Tong,Xiuxiu Xu,Zhongjun Dong,Rui Sun,Zhigang Tian,Haiming Wei +8 more
TL;DR: A CD49a+Eomes+ subset of NK cells that secreted growth‐promoting factors (GPFs), including pleiotrophin and osteoglycin, in both humans and mice was identified, revealing properties ofNK cells in promoting fetal growth.
Journal ArticleDOI
Roles of HLA-G in the Maternal-Fetal Immune Microenvironment.
TL;DR: Current findings about three main roles of HLA-G during pregnancy, namely its promotion of spiral artery remodeling, immune tolerance, and fetal growth, all resulting from its interaction with immune cells are summarized.