Recent insight into the biological activities of synthetic xanthone derivatives.

A ketone-assisted ruthenium-catalyzed selective amination of xanthones and chromones C–H bonds with sulfonyl azides is described. The reactions proceed efficiently with a broad range of substrates with excellent functional group compatibility. This protocol provides direct access to 1-aminoxanthones, 5-aminochromones, and 5-aminoflavonoid derivatives known to exhibit potent anticancer activity.

Yonghong Yan

Papers

First identification of xanthone sulfonamides as potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors.