▪ Abstract Recent studies showing that detergent-resistant membrane fragments can be isolated from cells suggest that biological membranes are not always in a liquid-crystalline phase. Instead, sph...

Functions of lipid rafts in biological membranes.

Structure and function of sphingolipid- and cholesterol-rich membrane rafts.

Lipid Rafts: Elusive or Illusive?

Membrane lipids are essential for biological functions ranging from membrane trafficking to signal transduction. The composition of lipid membranes influences their organization and properties, so it is not surprising that disorders in lipid metabolism and transport have a role in human disease. Significant recent progress has enhanced our understanding of the molecular and cellular basis of lipid-associated disorders such as Tangier disease, Niemann-Pick disease type C and atherosclerosis. These insights have also led to improved understanding of normal physiology.

https://web.iitd.ac.in/~amittal/nature04399.pdf

Role of cholesterol and lipid organization in disease.

https://www.cell.com/biophysj/pdf/S0006-3495(03)74664-5.pdf

Sphingomyelin/phosphatidylcholine/cholesterol phase diagram: boundaries and composition of lipid rafts

Cholesterol and Sphingolipid Enhance the Triton X-100 Insolubility of Glycosylphosphatidylinositol-anchored Proteins by Promoting the Formation of Detergent-insoluble Ordered Membrane Domains

Yongze Zhu

Papers

Cholesterol and Sphingolipid Enhance the Triton X-100 Insolubility of Glycosylphosphatidylinositol-anchored Proteins by Promoting the Formation of Detergent-insoluble Ordered Membrane Domains