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Yorinobu Maeda
Researcher at Hiroshima University
Publications - 32
Citations - 229
Yorinobu Maeda is an academic researcher from Hiroshima University. The author has contributed to research in topics: Chemistry & Prodrug. The author has an hindex of 8, co-authored 28 publications receiving 208 citations.
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Journal ArticleDOI
Dosage adjustment of ribavirin based on renal function in Japanese patients with chronic hepatitis C.
Yorinobu Maeda,Yoshie Kiribayashi,Takashi Moriya,Akira Maruhashi,Kei Omoda,Sachiyo Funakoshi,Teruo Murakami,Mikihisa Takano +7 more
TL;DR: Results indicate that CLtotal of ribavirin is dependent on renal function (creatinine clearance), and hemolysis is induced by high Ribavirin concentrations in plasma.
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Correlation between plasma concentration ratios of SN-38 glucuronide and SN-38 and neutropenia induction in patients with colorectal cancer and wild-type UGT1A1 gene
Koichi Hirose,Chihiro Kozu,Koshiro Yamashita,Eiji Maruo,Mizuho Kitamura,Junichi Hasegawa,Kei Omoda,Teruo Murakami,Yorinobu Maeda +8 more
TL;DR: UGT activity involved in SN-38 metabolism is variable among patients with the wild-type UGT1A1 gene, and each CPT-11 treatment suppresses UGT activity, according to a modified high-performance liquid chromatography method.
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Increased erythrocyte distribution of valproic acid in pharmacokinetic interaction with carbapenem antibiotics in rat and human
Kei Omoda,Teruo Murakami,Ryoko Yumoto,Junya Nagai,Yorinobu Maeda,Yoshie Kiribayashi,Mikihisa Takano +6 more
TL;DR: The pharmacokinetic interaction between VPA and carbapenem antibiotics, in which plasma VPA levels were markedly reduced, may partly be derived from the increased erythrocyte distribution of VPA.
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Interaction of magnesium oxide with gastric acid secretion inhibitors in clinical pharmacotherapy
Miho Yamasaki,Sachiyo Funakoshi,Shohei Matsuda,Tomoko Imazu,Yoshiaki Takeda,Teruo Murakami,Yorinobu Maeda +6 more
TL;DR: Higher dosing level of MgO or another laxative should be used in patients taking H2RA or PPI, as well as the case of patients with total gastric resection, due to the low solubility of MGO at the higher gastric pH and less generation of M gCl2 and Mg(HCO3)2.
Journal ArticleDOI
Prevention of irinotecan-induced diarrhoea by oral carbonaceous adsorbent (Kremezin) in cancer patients.
Yorinobu Maeda,Terumasa Ohune,Mamoru Nakamura,Miho Yamasaki,Yoshie Kiribayashi,Teruo Murakami +5 more
TL;DR: The results suggested that the oral Kremezin is effective in ameliorating C PT-11-induced diarrhoea without decreasing much the plasma clearance of CPT-11.