Y
Yoshiaki Takada
Researcher at National Institutes of Health
Publications - 4
Citations - 862
Yoshiaki Takada is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Blood–brain barrier & Amino acid. The author has an hindex of 4, co-authored 4 publications receiving 779 citations.
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Journal ArticleDOI
Blood–Brain Barrier Transport of Kynurenines: Implications for Brain Synthesis and Metabolism
TL;DR: The results demonstrate the saturable transfer of L‐KYN across the blood–brain barrier and suggest that circulating L‐ KYN, 3‐HKYN, and ANA may each contribute significantly to respective cerebral pools under normal conditions.
Journal ArticleDOI
Facilitated Transport of the Neurotoxin, β-N-Methylamino-l-Alanine, Across the Blood-Brain Barrier
TL;DR: The results demonstrate that BMAA is taken up into brain by the large neutral amino acid camer of the blood‐brain bamer and suggest that uptake may be sensitive to the same factors that affect neutral aminoacid transport, such as diet, metabolism, disease, and age.
Journal Article
Rapid high-affinity transport of a chemotherapeutic amino acid across the blood-brain barrier.
Yoshiaki Takada,David T. Vistica,Nigel H. Greig,David Purdon,Stanley I. Rapoport,Quentin R. Smith +5 more
TL;DR: The results demonstrate that drug modification to produce high-affinity ligands for the cerebrovascular nutrient carriers is a viable means to enhance drug delivery to brain for the treatment of brain tumors and other central nervous system disorders.
Journal ArticleDOI
Affinity of antineoplastic amino acid drugs for the large neutral amino acid transporter of the blood-brain barrier.
TL;DR: d,l-NAM may be a promising agent which may show enhanced uptake and distribution to brain tumors and the results suggest that the blood-brain barrier penetrability of most endogenous neutral amino acids is related to their carrier affinity.