Yoshiharu Machida

TL;DR: Chi is considered to be highly biodegradable and easily excreted in urine, and further it is suggested to have no problem on accumulation in the body; however, at the same time, Chi is found not to operate as a polymer support showing long retention in theBody.

TL;DR: Chitin and chitosan derivatives are used as excipients and drug carriers in the pharmaceutical field and their derivatization contributed to expansion of application and decrease toxicity.

TL;DR: A potentially suitable dosage form for the administration of insulin by injections was developed and tested in beagle dogs, indicating that sodium glycocholate effectively promoted the absorption of insulin from the oral mucosa.

TL;DR: The conjugates of MMC with Suc-Chi showed good antitumour activities against various tumours such as murine leukaemias, B16 melanoma, Sarcoma 180 solid tumour, a murine liver metastatic tumour and a murines hepatic cell carcinoma.

TL;DR: Novel wound dressings composed of chitosan (CH) film and minocycline hydrochloride (MH) were prepared using commercial polyurethane film (Tegaderm) as a backing, and CH83-MH2-A is suggested as a useful formulation for the treatment of severe burn wounds.